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Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability

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Acknowledgements

This work was supported by grants provided by New York University Abu Dhabi as well as grants from the Swedish Research Council (Vetenskapsrådet) and the Swedish Cancer Society (Cancerfonden) to PP. We thank the NYU Abu Dhabi Center for Genomics and Systems Biology, particularly Marc Arnoux and Mehar Sultana, for technical help and the Core Technology Platform Resources. We appreciate the computational platform provided by the NYUAD HPC team and are especially thankful to Nizar Drou for technical help.

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Authors and Affiliations

  1. Science Division, Biology Program, New York University Abu Dhabi (NYUAD), P.O. Box 129188, Abu Dhabi, United Arab Emirates

    Xin Xie, Martin Endara-Coll, Raza Mahmood, Robertas Jankauskas, Tamara Gjorgjieva & Piergiorgio Percipalle

  2. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91, Stockholm, Sweden

    Martin Endara-Coll & Piergiorgio Percipalle

  3. New York University Center for Genomics and Systems Biology, NYU, New York, NY, USA

    Raza Mahmood

Authors
  1. Xin Xie
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  2. Martin Endara-Coll
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  3. Raza Mahmood
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  4. Robertas Jankauskas
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  5. Tamara Gjorgjieva
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  6. Piergiorgio Percipalle
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Contributions

XX and PP conceived the project and designed the experiments. XX, MEC, RM, RJ, and TG performed the experiments. XX and PP analyzed the data and wrote the manuscript.

Corresponding author

Correspondence to Piergiorgio Percipalle.

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The authors declare no competing interests.

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Xie, X., Endara-Coll, M., Mahmood, R. et al. Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability. Cell Mol Immunol 16, 837–840 (2019). https://doi.org/10.1038/s41423-019-0269-2

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