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Antitumor immunity induced by the photodynamic action of BAM-SiPc, a silicon (IV) phthalocyanine photosensitizer

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References

  1. Fong W. P., Yeung H. Y., Lo P. C., Ng D. K. Photodynamic therapy. In: Ho A. H., Kim D., Somekh M. G., editors. Handbook of Photonics for Biomedical Engineering. 1–20 (Springer Science+Business Media, Dordrecht, 2014).

    Google Scholar 

  2. Abrahamse, H. & Hamblin, M. R. New photosensitizers for photodynamic therapy. Biochem J. 473, 347–364 (2016).

    Article  CAS  Google Scholar 

  3. Siddiqui, M. R. et al. Targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) expressing bladder cancer using combination photoimmunotherapy (PIT). Sci. Rep. 9, 2084 (2019).

    Article  Google Scholar 

  4. Preise, D. et al. Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity. Cancer Immunol. Immunother. 58, 71–84 (2009).

    Article  CAS  Google Scholar 

  5. Lo, P. C. et al. New amphiphilic silicon(IV) phthalocyanines as efficient photosensitizers for photodynamic therapy: synthesis, photophysical properties, and in vitro photodynamic activities. Chem. Eur. J. 10, 4831–4838 (2004).

    Article  CAS  Google Scholar 

  6. Yeung, H. Y., Lo, P. C., Ng, D. K. & Fong, W. P. Anti-tumor immunity of BAM-SiPc-mediated vascular photodynamic therapy in a BALB/c mouse model. Cell Mol. Immunol. 14, 223–234 (2017).

    Article  CAS  Google Scholar 

  7. Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol. 17, 97–111 (2017).

    Article  CAS  Google Scholar 

  8. Zhou, Y. et al. Endoplasmic reticulum-localized two-photon-absorbing boron dipyrromethenes as advanced photosensitizers for photodynamic therapy. J. Med. Chem. 61, 3952–3961 (2018).

    Article  CAS  Google Scholar 

  9. Chen, Z. et al. Bioinspired hybrid protein oxygen nanocarrier amplified photodynamic therapy for eliciting anti-tumor immunity and abscopal effect. ACS Nano 12, 8633–8645 (2018).

    Article  CAS  Google Scholar 

  10. Song, W. et al. Enhanced immunotherapy based on photodynamic therapy for both primary and lung metastasis tumor eradication. ACS Nano 12, 1978–1989 (2018).

    Article  CAS  Google Scholar 

  11. O'Shaughnessy, M. J. et al. Systemic antitumor immunity by PD-1/PD-L1 inhibition is potentiated by vascular-targeted photodynamic therapy of primary tumors. Clin. Cancer Res. 24, 592–599 (2018).

    Article  CAS  Google Scholar 

  12. Zheng, Y. et al. Photodynamic-therapy activates immune response by disrupting immunity homeostasis of tumor cells, which generates vaccine for cancer therapy. Int J. Biol. Sci. 12, 120–132 (2016).

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region China [Project no. CUHK 14171717].

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Correspondence to Wing-Ping Fong.

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Zhang, Y., Ng, D.K.P. & Fong, WP. Antitumor immunity induced by the photodynamic action of BAM-SiPc, a silicon (IV) phthalocyanine photosensitizer. Cell Mol Immunol 16, 676–678 (2019). https://doi.org/10.1038/s41423-019-0239-8

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