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Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades

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References

  1. Chakraborty, B. et al. Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma. Cell. Mol. Immunol. 13, 191–205 (2016).

    Article  CAS  Google Scholar 

  2. Hegedus, C. et al. Redox control of cancer cell destruction. Redox Biol. 16, 59–74 (2018).

    Article  CAS  Google Scholar 

  3. Pal, R. et al. Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: an in vitro approach. Int. Immunopharmacol. 38, 332–341 (2016).

    Article  CAS  Google Scholar 

  4. Wang, R. et al. Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer. J. Exp. Clin. Cancer Res. 30, 62–62 (2011).

    Article  Google Scholar 

  5. Cortez-Retamozo, V. et al. Origins of tumor-associated macrophages and neutrophils. Proc. Natl Acad. Sci. USA 109, 2491–2496 (2012).

    Article  CAS  Google Scholar 

  6. Nath, A. et al. Gold-manganese oxide nanocomposite suppresses hypoxia and augments pro-inflammatory cytokines in tumor associated macrophages. Int. Immunopharmacol. 57, 157–164 (2018).

    Article  CAS  Google Scholar 

  7. Nagy, M. A. HIF-1 is the commander of gateways to cancer. J. Cancer Sci. Ther. 3, 35–40 (2011).

    CAS  Google Scholar 

  8. Manke, A., Wang, L. & Rojanasakul, Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed. Res. Int. 2013, 15 (2013).

    Article  Google Scholar 

  9. Navalon, S., de Miguel, M., Martin, R., Alvaro, M. & Garcia, H. Enhancement of the catalytic activity of supported gold nanoparticles for the Fenton reaction by light. J. Am. Chem. Soc. 133, 2218–2226 (2011).

    Article  CAS  Google Scholar 

  10. Adeyemi, O. S. & Faniyan, T. O. Antioxidant status of rats administered silver nanoparticles orally. J. Taibah Univ. Med. Sci. 9, 182–186 (2014).

    Google Scholar 

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Correspondence to Mahuya Sengupta.

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Sengupta, M., Pal, R., Nath, A. et al. Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades. Cell Mol Immunol 15, 1088–1090 (2018). https://doi.org/10.1038/s41423-018-0046-7

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