References
Chakraborty, B. et al. Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma. Cell. Mol. Immunol. 13, 191–205 (2016).
Hegedus, C. et al. Redox control of cancer cell destruction. Redox Biol. 16, 59–74 (2018).
Pal, R. et al. Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: an in vitro approach. Int. Immunopharmacol. 38, 332–341 (2016).
Wang, R. et al. Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer. J. Exp. Clin. Cancer Res. 30, 62–62 (2011).
Cortez-Retamozo, V. et al. Origins of tumor-associated macrophages and neutrophils. Proc. Natl Acad. Sci. USA 109, 2491–2496 (2012).
Nath, A. et al. Gold-manganese oxide nanocomposite suppresses hypoxia and augments pro-inflammatory cytokines in tumor associated macrophages. Int. Immunopharmacol. 57, 157–164 (2018).
Nagy, M. A. HIF-1 is the commander of gateways to cancer. J. Cancer Sci. Ther. 3, 35–40 (2011).
Manke, A., Wang, L. & Rojanasakul, Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed. Res. Int. 2013, 15 (2013).
Navalon, S., de Miguel, M., Martin, R., Alvaro, M. & Garcia, H. Enhancement of the catalytic activity of supported gold nanoparticles for the Fenton reaction by light. J. Am. Chem. Soc. 133, 2218–2226 (2011).
Adeyemi, O. S. & Faniyan, T. O. Antioxidant status of rats administered silver nanoparticles orally. J. Taibah Univ. Med. Sci. 9, 182–186 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Publisher's note:
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Conflict of interest
The authors declare that there are no conflict of interest.
Rights and permissions
About this article
Cite this article
Sengupta, M., Pal, R., Nath, A. et al. Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades. Cell Mol Immunol 15, 1088–1090 (2018). https://doi.org/10.1038/s41423-018-0046-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41423-018-0046-7
- Springer Nature Limited
Keywords
This article is cited by
-
Alteration in Inflammasome Cytokine Profile and Functional Plasticity of Macrophage Phenotype in Arsenic(0) Nanoparticle Treated Murine Fibrosarcoma
BioNanoScience (2022)
-
Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
Nature Communications (2020)
-
BRD4 promotes tumor progression and NF-κB/CCL2-dependent tumor-associated macrophage recruitment in GIST
Cell Death & Disease (2019)