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Hypophosphatemia and pre-infusion thrombocytopenia as biomarkers for CRS and ICANS after CAR T therapy

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Fig. 1: Each biomarker was investigated up to 25 days after infusion looking for either nadir or peak levels.

References

  1. Hay KA, Hanafi LA, Li D, Gust J, Liles CW, Wurfel MM, et al. Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy. Blood. 2017;130:2295.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tedesco VE, Mohan C. Biomarkers for predicting cytokine release syndrome following CD19 -targeted CAR T cell therapy. J Immunol. 2021;206:1561–8.

    Article  PubMed  Google Scholar 

  3. Wang Z, Han W. Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy. Biomark Res. 2018;6:4 https://doi.org/10.1186/S40364-018-0116-0.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Tang JP, Peters CW, Quiros C, Wang X, Klomhaus AM, Yamada RE, et al. Hypophosphatemia due to increased effector cell metabolic activity is associated with neurotoxicity symptoms in CD19-targeted CAR T-cell therapy. Cancer Immunol Res. 2022;10:1433–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nakamura N, Arai Y, Kitawaki T, Jo T, Mizumoto C, Kanda J, et al. Decreased serum phosphate levels are a useful biomarker to predict occurrence and severity of cytokine release syndrome in chimeric antigen receptor T-cell therapy. Br J Haematol. 2023;200:e1–e3.

    Article  CAS  PubMed  Google Scholar 

  6. Brindle NPJ, Saharinen P, Alitalo K. Signalling and functions of angiopoietin-1 in vascular protection. Circ Res. 2006;98:1014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pizurki L, Zhou Z, Glynos K, Roussos C, Papapetropoulos A. Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. Br J Pharm. 2003;139:329.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, University of Arizona, Tucson, AZ, USA

    Kenneth Barker & Muhammad Husnain

  2. University of Arizona Cancer Center, Tucson, AZ, USA

    Shannon Koza, Emmanuel Katsanis & Muhammad Husnain

  3. Departments of Immunobiology, Medicine, and Pathology, University of Arizona, Tucson, AZ, USA

    Emmanuel Katsanis

  4. Department of Pediatrics, University of Arizona, Tucson, AZ, USA

    Emmanuel Katsanis

Authors
  1. Kenneth Barker
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  2. Shannon Koza
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  3. Emmanuel Katsanis
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  4. Muhammad Husnain
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Contributions

KB collected and analyzed the data and wrote the manuscript. SK contributed the original idea for the project. MH and EK contributed to project design/oversight and editing of the manuscript. All authors revised and approved the final manuscript.

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Correspondence to Kenneth Barker.

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The authors declare no competing interests.

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Barker, K., Koza, S., Katsanis, E. et al. Hypophosphatemia and pre-infusion thrombocytopenia as biomarkers for CRS and ICANS after CAR T therapy. Bone Marrow Transplant 58, 1267–1269 (2023). https://doi.org/10.1038/s41409-023-02083-4

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  • DOI: https://doi.org/10.1038/s41409-023-02083-4

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