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Microbiota dysbiosis after high-dose melphalan and autologous hematopoietic cell transplantation in multiple myeloma

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Fig. 1: Gut microbiota diversity during transplantation period.

References

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Acknowledgements

The authors acknowledge the « af3m, Association Française des Malades du Myélome Multiple » and the « IFM, Intergroupe Francophone du Myélome » for their support. The authors acknowledge the “Tumorothèque” of the Clinical Haematology Department at Saint-Antoine hospital for logistical support for handling of samples. The authors acknowledge the Association for Training, Education and Research in Hematology, Immunology and Transplantation for the generous and continuous support of the research work. We thank our nursing staff for offering the best care to our patients.

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Authors and Affiliations

  1. Sorbonne Université, APHP, Hôpital Saint Antoine, Service d’Hématologie Clinique et de Thérapie cellulaire, Paris, France

    Florent Malard, Giorgia Battipaglia, Zoe van de Wyngaert, Agnes Bonnin, Rémy Duléry, Anne Banet, Nicolas Stocker, Laure Ricard, Eolia Brissot & Mohamad Mohty

  2. INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012, Paris, France

    Florent Malard, Giorgia Battipaglia, Béatrice Gaugler, Lama Siblany, Zoe van de Wyngaert, Agnes Bonnin, Rémy Duléry, Anne Banet, Nicolas Stocker, Laure Ricard, Eolia Brissot & Mohamad Mohty

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  1. Florent Malard
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Contributions

FM designed the study, recruited patients, performed experimental work, collected, assembled and analyzed data, and wrote and revised the manuscript. GB recruited patients, collected and assembled data, and helped write the manuscript. BG, LS, NS and LR, performed experimental work, collected, assembled, analyzed data, and helped write the manuscript. ZW, ABo, RD, ABa and EB recruited patients, collected data and helped write the manuscript. MM designed the study, supervised research, analyzed data and helped write the manuscript.

Corresponding author

Correspondence to Florent Malard.

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Competing interests

FM reports lecture honoraria from, Therakos/Mallinckrodt, Janssen, Sanofi, JAZZ Pharmaceuticals, Gilead, Novartis, and Bristol Myers Squibb, all outside the submitted work. MM reports grants and lecture honoraria from Janssen, Sanofi, Maat Pharma and JAZZ Pharmaceuticals, lecture honoraria from Celgene, Amgen, BMS, Takeda, and Pfizer, grants from Roche, all outside the submitted work. The other authors declare no competing financial interests. RD reports research funding from Ligue contre le Cancer, Arthur Sachs, Monahan Foundation, Servier Foundation, Philippe Foundation, DCP AP-HP, honoraria from Novartis and Takeda, non-financial support from Kite Pharma/Gilead, all outside the submitted work.

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Malard, F., Battipaglia, G., Gaugler, B. et al. Microbiota dysbiosis after high-dose melphalan and autologous hematopoietic cell transplantation in multiple myeloma. Bone Marrow Transplant 58, 1275–1278 (2023). https://doi.org/10.1038/s41409-023-02078-1

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