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Influence of pretransplant inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis study from the Transplant Complications Working Party (TCWP) of the EBMT

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Fig. 1: Transplantation outcomes of the study population.

References

  1. Sorror ML, Maris MB, Storb RF, Baron F, Sandmaier BM, Maloney DG, et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106:2912–9.

    Article  CAS  Google Scholar 

  2. Sorror ML, Martin PJ, Storb RF, Bhatia S, Maziarz RT, Pulsipher MA, et al. Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality. Blood. 2014;124:287–95.

    Article  CAS  Google Scholar 

  3. Rabian F, Porcher R, Sicre de Fontbrune F, Lioure B, Laplace A, Nguyen S, et al. Influence of previous inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis. Biol Blood Marrow Transplant. 2016;22:1721–4.

    Article  Google Scholar 

  4. Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Mucosal Immunol. 2015;8:720–30.

    Article  CAS  Google Scholar 

  5. Shono Y, van den Brink M. Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18:283–95.

    Article  CAS  Google Scholar 

  6. Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, Andoh A. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin J Gastroenterol. 2018;11:1–10.

    Article  Google Scholar 

  7. Opazo M, Ortega-Rocha E, Corronado-Arrazola I, Bonifaz LC, Boudin, Neunlist M, et al. Intestinal microbiota influences non-intestinal related autoimmune diseases. Front Microbiol. 2018;9:432.

    Article  Google Scholar 

  8. Greco R, Labopin M, Badoglio M, Veys P, Furtado Silva JM, Abinun M, et al. Allogeneic HSCT for autoimmune disorders: a retrospective study from the EBMT, ADWP, IEWP and PDWP Working Parties. Front Immunol. 2019;10:1570.

    Article  CAS  Google Scholar 

  9. Snowden JA, Panes J, Alexander T, Allez M, Ardizzone S, Dierickx D, et al. Autologous hematopoietic stem cell transplantation (AHSCT) in severe Crohn’s disease: a review on behalf of ECCO and EBMT. J Crohns Colitis. 2018;12:476–88.

    Article  Google Scholar 

  10. Snowden JA, Hawkey C, Hind D, Swaby L, Mellor K, Emsley R, et al. Autologous stem cell transplantation in refractory Crohn’s disease—low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterol. 2019;19:82.

    Article  Google Scholar 

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Authors and Affiliations

  1. University Hospital Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia

    Zinaida Peric

  2. EBMT Paris Study Office, Department of Haematology, Saint Antoine Hospital, INSERM UMR 938, Sorbonne University, Paris, France

    Christophe Peczynski & Emmanuelle Polge

  3. University Hospital Eppendorf, Bone Marrow Transplantation Centre, Hamburg, Germany

    Nicolaus Kröger

  4. Bone Marrow Transplant Unit, National University Hospital, Rigshospitalet, Copenhagen, Denmark

    Henrik Sengeloev

  5. Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany

    Aleksandar Radujkovic

  6. Silesian Medical Academy, Univ. Dept. of Haematology and BMT, Katowice, Poland

    Grzegorz Helbig

  7. Nottingham University, Nottingham, UK

    Nigel Russell

  8. Klinik fuer Innere Medzin III, Universitätsklinikum Ulm, Ulm, Germany

    Donald Bunjes

  9. Dept.of Hematology—BMT, Hopital St. Louis, Paris, France

    Gerard Socié

  10. GKT School of Medicine, Dept. of Haematological Medicine, King’s Denmark Hill Campus, London, UK

    Victoria Potter

  11. Dept. of Bone Marrow Transplantation, University Hospital, Essen, Germany

    Dietrich Beelen

  12. Department of Haematology, Addenbrookes Hospital, Cambridge, UK

    Charles Crawley

  13. Adult Leukaemia and Bone Marrow Transplant Unit, Christie NHS Trust Hospital, Manchester, UK

    Adrian Bloor

  14. Department of Medicine—Hematology, Oncology and Medical Faculty University Freiburg, University of Freiburg, Freiburg im Breisgau, Germany

    Jürgen Finke

  15. Department of Hematology, University Hospitals Leuven, KU Leuven, Leuven, Belgium

    Helene Schoemans

  16. Department of Hematology, Oncology and Tumorimmunology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany

    Olaf Penack

  17. Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

    John A. Snowden

  18. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation and Institute of Immunology, Hannover, Germany

    Christian Koenecke

  19. Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warszawa, Poland

    Grzegorz W. Basak

Authors
  1. Zinaida Peric
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  2. Christophe Peczynski
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  3. Emmanuelle Polge
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  4. Nicolaus Kröger
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  5. Henrik Sengeloev
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  6. Aleksandar Radujkovic
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  7. Grzegorz Helbig
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  8. Nigel Russell
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  9. Donald Bunjes
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  10. Gerard Socié
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  11. Victoria Potter
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  12. Dietrich Beelen
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  13. Charles Crawley
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  14. Adrian Bloor
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  15. Jürgen Finke
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  16. Helene Schoemans
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  17. Olaf Penack
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  18. John A. Snowden
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  19. Christian Koenecke
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  20. Grzegorz W. Basak
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Contributions

ZP assembled and analyzed data and wrote the first version of the paper. CK, HS, OP, and GB designed the study, supervised research, analyzed data, and helped with writing the paper. EP and CP assembled the data, performed statistical analysis, and commented on the paper. All other co-authors collected data, recruited patients, and helped with writing the paper. All authors approved submission of the paper for publication.

Corresponding author

Correspondence to Zinaida Peric.

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The authors declare no competing interests.

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Peric, Z., Peczynski, C., Polge, E. et al. Influence of pretransplant inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis study from the Transplant Complications Working Party (TCWP) of the EBMT. Bone Marrow Transplant 56, 3084–3087 (2021). https://doi.org/10.1038/s41409-021-01458-9

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