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Mesenchymal stromal cell therapy induces high responses and survival in children with steroid refractory GVHD and poor risk biomarkers

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Fig. 1: Baseline characteristics and 6-month survival of SR acute GVHD patients according to treatment.

References

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Funding

National Cancer Institute (P01CA039542 and P30CA196521), the Pediatric Cancer Foundation, and Mesoblast provided funding for this study.

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Author notes

  1. These authors contributed equally: John E. Levine, James L. M. Ferrara.

Authors and Affiliations

  1. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Stelios Kasikis, Janna Baez, Isha Gandhi, Steven Kowalyk, George Morales, Rachel Young, John E. Levine & James L. M. Ferrara

  2. Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Stephan Grupp

  3. Vanderbilt University Medical Center, Nashville, TN, USA

    Carrie L. Kitko

  4. Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Pietro Merli

  5. Section of Transplantation and Cellular Therapy, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Michael A. Pulsipher

  6. Aflac Cancer and Blood Disorders Center, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA, USA

    Muna Qayed

  7. Children’s Hospital, University of Würzburg, Würzburg, Germany

    Matthias Wölfl

  8. University of Michigan, Ann Arbor, MI, USA

    Gregory Yanik

  9. Mesoblast, Inc., New York, NY, USA

    Fiona See, Jack Hayes, Fred Grossman & Elizabeth Burke

Authors
  1. Stelios Kasikis
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  16. Elizabeth Burke
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  17. Rachel Young
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  18. John E. Levine
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  19. James L. M. Ferrara
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Corresponding author

Correspondence to James L. M. Ferrara.

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Competing interests

FS, JH, FG and EB are employees of Mesoblast. JEL and JLMF have received consulting fees from Mesoblast and royalties from a GVHD biomarker patent.

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Kasikis, S., Baez, J., Gandhi, I. et al. Mesenchymal stromal cell therapy induces high responses and survival in children with steroid refractory GVHD and poor risk biomarkers. Bone Marrow Transplant 56, 2869–2870 (2021). https://doi.org/10.1038/s41409-021-01442-3

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