Skip to main content

Advertisement

SpringerLink
Log in

Outcomes of conditioning with rabbit antithymocyte globulin and rituximab in haploidentical haematopoietic stem cell transplantation in patients with severe aplastic anaemia

  • Correspondence
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Patient overall survival (OS) and GVHD-free, failure-free survival (GFFS) as assessed using Kaplan−Meier analysis.

References

  1. Bacigalupo A. Alternative donor transplants for severe aplastic anemia. Hematol Am Soc Hematol Educ Progr. 2018;1:467–73.

  2. Walker I, Panzarella T, Couban S, Couture F, Devins G, Elemary M, et al. Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial. Lancet Oncol. 2016;17:164–73.

    Article  CAS  Google Scholar 

  3. Christopeit M, Schutte V, Theurich S, Weber T, Grothe W, Behre G. Rituximab reduces the incidence of acute graft-versus-host disease. Blood. 2009;113:3130–1.

    Article  CAS  Google Scholar 

  4. Liu L, Liu S, Zhang Y, Zhou H, Wang Q, Tian H, et al. Excellent outcomes of allogeneic hematopoietic stem cell transplantation in patients with paroxysmal nocturnal hemoglobinuria: a single-center study. Biol Blood Marrow Transpl. 2019;25:1544–9.

    Article  Google Scholar 

  5. Xu LP, Jin S, Wang SQ, Xia LH, Bai H, Gao SJ, et al. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant. J Hematol Oncol. 2017;10:25.

    Article  Google Scholar 

  6. Sarantopoulos S, Blazar BR, Cutler C, Ritz JB. Cells in chronic graft versus host disease. Biol Blood Marrow Transpl. 2015;21:16–23.

    Article  CAS  Google Scholar 

  7. Focosi D, Zucca A, Scatena F. The role of anti-HLA antibodies in hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2011;17:1585–8.

  8. Pan Z, Yuan X, Li Y, Wu X, Zhu W, Bao X, et al. Dynamic detection of antieHuman leukocyte antigen (HLA) antibodies but not HLA-DP loci mismatches can predict acute graft-versus-host disease and overall survival in HLA 12/12 matched unrelated donor allogeneic hematopoietic stem cell transplantation for hematological malignancies. Biol Blood Marrow Transpl. 2016;22:86–95.

    Article  CAS  Google Scholar 

  9. Xu LP, Wang SQ, Wu DP, Wang JM, Gao SJ, Jiang M, et al. Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study. Br J Haematol. 2016;175:265–74.

    Article  Google Scholar 

Download references

Acknowledgements

This work was partly supported by grants from National Key R&D Program of China (2016YFC0902800, 2017YFA0104502, 2017ZX09304021), Innovation Capability Development Project of Jiangsu Province (BM2015004), Jiangsu Provincial Key Medical Center (YXZXA2016002), Jiangsu Medical Outstanding Talents Project (JCRCA2016002) and Priority Academic Program Development of Jiangsu Higher Education Institutions.

Author information

Author notes

  1. These authors contributed equally: Limin Liu, Yanming Zhang, Shan Liu

Authors and Affiliations

  1. The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology, 188 Shizi Street, Suzhou, 215006, Jiangsu, China

    Limin Liu, Huifen Zhou, Qingyuan Wang, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Suning Chen, Aining Sun, Miao Miao & Depei Wu

  2. Department of Hematology, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, No 62, Huaihai Road (S.), Huai’an, China

    Yanming Zhang

  3. Department of Laboratory Medicine, Affiliated Hospital of University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China

    Shan Liu

Authors
  1. Limin Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yanming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huifen Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Qingyuan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Huiying Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xiaowen Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yue Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Chengcheng Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Zhengming Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Suning Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Aining Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Miao Miao
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Depei Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Miao Miao or Depei Wu.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, L., Zhang, Y., Liu, S. et al. Outcomes of conditioning with rabbit antithymocyte globulin and rituximab in haploidentical haematopoietic stem cell transplantation in patients with severe aplastic anaemia. Bone Marrow Transplant 55, 1854–1856 (2020). https://doi.org/10.1038/s41409-020-0788-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-020-0788-6

  • Springer Nature Limited

This article is cited by

Search

Navigation