Abstract
Recent studies in both mice and humans have demonstrated that the intestinal microbiota can affect hematopoiesis. Here, we performed experiments in preclinical mouse models for syngeneic and allogeneic HCT. To study the metabolic effects of intestinal flora depletion on post-transplant hematopoiesis in humans, we performed HCT experiments using a metabolic chamber and bomb calorimetry of feces. Taken together, we show that the intestinal microbiota supports post-transplant hematopoietic reconstitution in HCT recipients through its role in dietary energy uptake.
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Funding
Publication of this supplement was sponsored by Gilead Sciences Europe Ltd, Cell Source, Inc., The Chorafas Institute for Scientific Exchange of the Weizmann Institute of Science, Kiadis Pharma, Miltenyi Biotec, Celgene, Centro Servizi Congressuali, Almog Diagnostic.
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MvdB received consulting fees from Seres Therapeutics, TTT Study Section, owns equity in Epiva & Evelo Theaputics, and received grant support from Seres Therapeutics, NIH, Susan and Peter Solomon Fund, and Parker Institute for Cancer Immunology. AS received grants from the Swedish research council (VR), the Swedish society for medical research (SSMF) and Assar Gabrielsson Foundation (AG Fond). There are no conflicts of interest to disclose.
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Staffas, A., van den Brink, M. The intestinal flora is required for post-transplant hematopoiesis in recipients of a hematopoietic stem cell transplantation. Bone Marrow Transplant 54 (Suppl 2), 756–758 (2019). https://doi.org/10.1038/s41409-019-0612-3
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DOI: https://doi.org/10.1038/s41409-019-0612-3
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