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Initialization of epithelial cells by tumor cells in a metastatic microenvironment

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Fig. 1: CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.
Fig. 2: Identified CD90-positive stem-like cells in normal neighboring alveolar epithelial cells.

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Acknowledgements

This study was supported in part by grants from the Japan Ministry of Education, Culture, Science and Technology (nos. 24592510, 15K1079, and 19K09840), The Foundation of Osaka Cancer Research, The Ichiro Kanehara Foundation of the Promotion of Medical Science and Medical Care, The Foundation for the Promotion of Cancer Research, The Kanzawa Medical Research Foundation, and The Takeda Foundation for Medical Science.

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Authors and Affiliations

  1. National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, Japan

    Takuma Hayashi & Ikuo Konishi

  2. Department of Medical Laboratory, Shinshu University Hospital, Nagano, Japan

    Takuma Hayashi & Kenji Sano

  3. Genome Science Laboratory, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

    Hiroyuki Aburatani

  4. International Cancer Genome Consortium: ICGC, Tasmania, Australia

    Hiroyuki Aburatani

  5. Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan

    Nobuo Yaegashi

  6. Immediate Past President of Asian Society of Gynecologic Oncology, Tokyo, Japan

    Ikuo Konishi

Authors
  1. Takuma Hayashi
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  2. Kenji Sano
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  3. Hiroyuki Aburatani
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  4. Nobuo Yaegashi
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  5. Ikuo Konishi
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Contributions

TH and KS performed most of the experiments and coordinated the project; KS performed cell sorting and the flow cytometric analysis by BD FACSAria™ III; TH performed xenograft studies for the micrometastasis model; TH, KS, and HA were involved in pathology assessments and the detection of CD90-positive stem-like cells; TH conceived the study and wrote the paper. NY and IK gave information on clinical medicine and oversaw the entire study.

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Correspondence to Takuma Hayashi.

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Hayashi, T., Sano, K., Aburatani, H. et al. Initialization of epithelial cells by tumor cells in a metastatic microenvironment. Oncogene 39, 2638–2640 (2020). https://doi.org/10.1038/s41388-020-1171-1

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