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Purinergic system and suicidal behavior: exploring the link between adenosine A2A receptors and depressive/impulsive features

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References

  1. Krügel U. Purinergic receptors in psychiatric disorders. Neuropharmacology. 2016;104:212–25.

    Article  Google Scholar 

  2. Ortiz R, Ulrich H, Zarate CA Jr, Machado-Vieira R. Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:117–31.

    Article  CAS  Google Scholar 

  3. Cheffer A, Castillo ARG, Corrêa-Velloso J, Gonçalves MCB, Naaldijk Y, Nascimento IC, et al. Purinergic system in psychiatric diseases. Mol Psychiatry. 2018;23:94–106.

    Article  CAS  Google Scholar 

  4. El Yacoubi M, Ledent C, Parmentier M, Bertorelli R, Ongini E, Costentin J, et al. Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol. 2001;134:68–77.

    Article  CAS  Google Scholar 

  5. Yamada K, Kobayashi M, Kanda T. Involvement of adenosine A2A receptors in depression and anxiety. Int Rev Neurobiol. 2014;119:373–93.

    Article  Google Scholar 

  6. Cunha GM, Canas PM, Oliveira CR, Cunha RA. Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience. 2006;141:1775–81.

    Article  CAS  Google Scholar 

  7. Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, et al. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proc Natl Acad Sci USA. 2015;112:7833–8.

    Article  CAS  Google Scholar 

  8. Lucas M, O’Reilly EJ, Pan A, Mirzaei F, Willett WC, Okereke OI, Ascherio A. Coffee, caffeine, and risk of completed suicide: results from three prospective cohorts of American adults. World J Biol Psychiatry. 2014;15:377–86.

    Article  Google Scholar 

  9. Elgün S, Keskinege A, Kumbasar H. Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in depression. Psychoneuroendocrinology. 1999;24:823–32.

    Article  Google Scholar 

  10. Bartoli F, Trotta G, Crocamo C, Malerba MR, Clerici M, Carrà G. Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression. Eur Arch Psychiatry Clin Neurosci. 2018;268:119–27.

    Article  Google Scholar 

  11. Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry. 2013;3:e212.

    Article  CAS  Google Scholar 

  12. Kaster MP, Rosa AO, Rosso MM, Goulart EC, Santos AR, Rodrigues AL. Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett. 2004;355:21–4.

    Article  CAS  Google Scholar 

  13. van Heeringen K, Mann JJ. The neurobiology of suicide. Lancet Psychiatry. 2014;1:63–72.

    Article  Google Scholar 

  14. Ernst C, Mechawar N, Turecki G. Suicide neurobiology. Prog Neurobiol. 2009;89:315–33.

    Article  CAS  Google Scholar 

  15. Sutin AR, Cutler RG, Camandola S, Uda M, Feldman NH, Cucca F, Zonderman AB, Mattson MP, Ferrucci L, Schlessinger D, Terracciano A. Impulsivity is associated with uric acid: evidence from humans and mice. Biol Psychiatry. 2014;75:31–7.

    Article  CAS  Google Scholar 

  16. Bartoli F, Crocamo C, Mazza MG, Clerici M, Carrà G. Uric acid levels in subjects with bipolar disorder: a comparative meta-analysis. J Psychiatr Res. 2016;81:133–9.

    Article  Google Scholar 

  17. Oliveros A, Cho CH, Cui A, Choi S, Lindberg D, Hinton D, Jang MH, Choi DS. Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. Transl Psychiatry. 2017;7:e1095.

    Article  Google Scholar 

  18. Deshpande G, Baxi M, Witte T, Robinson JL. A neural basis for the acquired capability for suicide. Front Psychiatry. 2016;7:125.

    Article  CAS  Google Scholar 

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Correspondence to Francesco Bartoli.

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Bartoli, F., Clerici, M. & Carrà, G. Purinergic system and suicidal behavior: exploring the link between adenosine A2A receptors and depressive/impulsive features. Mol Psychiatry 25, 512–513 (2020). https://doi.org/10.1038/s41380-018-0057-x

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