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MYELODYSPLASTIC NEOPLASM

Myelodysplastic neoplasm with isolated thrombocytopenia and immune thrombocytopenic purpura in adults: insights from a comparison of two national registries

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Fig. 1: Kaplan–Meier curve of overall survival and leukemia-free survival of patients with MDS-IT, as compared with patients in the general MDS cohort.
Fig. 2: Differentiating between MDS-IT and ITP.

Data availability

The original data of this study can be obtained via e-mail to Prof. I. Kotsianidis (ikotsian@med.duth.gr).

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Acknowledgements

We would like to thank all local investigators for their contribution to data acquisition for the Hellenic National Registry of Myelodysplastic and Hypoplastic Syndromes and the ITP Registry of the Hellenic Society of Hematology. We declare no funding for this research from any funding agency in the public, commercial, or not-for-profit sectors. There was no external funding for this research from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece

    Konstantinos Liapis, Vasileios Papadopoulos, George Vrachiolias, Menelaos Papoutselis, Stavros Papadakis & Ioannis Kotsianidis

  2. Department of Hematology, University General Hospital of Heraklion, Heraklion, Crete, Greece

    Charalambos Pontikoglou, Maria Ximeri & Helen A. Papadaki

  3. Department of Hematology, Benizeleion Hospital, Heraklion, Crete, Greece

    Emily Stavroulaki & Argiris Symeonidis

  4. Greece Department of Internal Medicine, University Hospital of Patras, Rio, Greece

    Alexandra Kourakli & Vasileios Lazaris

  5. Department of Clinical Hematology, Georgios Gennimatas Hospital, Athens, Greece

    Athanasios G. Galanopoulos & Dimitris Τsokanas

  6. Second Department of Internal Medicine, Attikon University General Hospital, Athens, Greece

    Sotirios G. Papageorgiou & Vassiliki Pappa

  7. First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Panagiotis T. Diamantopoulos & Nora-Athina Viniou

  8. Department of Hematology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece

    Theodoros P. Vassilakopoulos

  9. Department of Hematology, University Hospital of Ioannina, Ioannina, Greece

    Eleftheria Hatzimichael

  10. Department of Hematology, University Hospital of Larissa, Larissa, Greece

    Eleni Bouronikou

  11. Department of Hematology, Metaxa Oncology Hospital, Piraeus, Greece

    Aekaterini Megalakaki

  12. Department of Hematology, Aghios Andreas General Hospital, Patras, Greece

    Panagiotis Zikos

  13. First Propedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Panayiotis Panayiotidis & Maria Dimou

  14. Department of Hematology, Sotiria General Hospital, Athens, Greece

    Stamatis Karakatsanis

  15. Department of Hematology, AHEPA University Hospital, Thessaloniki, Greece

    Maria Papaioannou

  16. Department of Hematology and Stem cell Transplantation, Georgios Papanicolaou General Hospital, Thessaloniki, Greece

    Anna Vardi

  17. Second Department of Internal Medicine, National and Kapodistrian University of Athens, Hippokratio General Hospital, Athens, Greece

    Flora Kontopidou

  18. Department of Hematology and Bone Marrow Transplantation Unit, Evangelismos Hospital, Athens, Greece

    Nikolaos Harchalakis

  19. Department of Hematology and Thalassemia, Kalamata General Hospital, Kalamata, Greece

    Ioannis Adamopoulos

Authors
  1. Konstantinos Liapis
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  2. Vasileios Papadopoulos
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  3. Charalambos Pontikoglou
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  4. George Vrachiolias
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  6. Alexandra Kourakli
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  7. Vasileios Lazaris
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  8. Athanasios G. Galanopoulos
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  9. Menelaos Papoutselis
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  10. Sotirios G. Papageorgiou
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  11. Panagiotis T. Diamantopoulos
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  12. Vassiliki Pappa
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  13. Nora-Athina Viniou
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  14. Dimitris Τsokanas
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  15. Theodoros P. Vassilakopoulos
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  16. Eleftheria Hatzimichael
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  17. Eleni Bouronikou
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  18. Maria Ximeri
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  19. Aekaterini Megalakaki
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  20. Panagiotis Zikos
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  21. Panayiotis Panayiotidis
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  22. Maria Dimou
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  23. Stamatis Karakatsanis
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  24. Maria Papaioannou
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  25. Stavros Papadakis
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  26. Anna Vardi
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  27. Flora Kontopidou
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  28. Nikolaos Harchalakis
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  29. Ioannis Adamopoulos
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  30. Argiris Symeonidis
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  31. Helen A. Papadaki
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  32. Ioannis Kotsianidis
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Contributions

Contribution: IK conceived the idea for this study and designed the study. KL and V. Papadopoulos contributed to the concept of the study. KL, V. Papadopoulos, GV, and IK collected, analyzed and interpreted data and reviewed the literature. KL and IK drafted the manuscript. ES, AK, CP, AGG, MP, SGP, PTD, V. Pappa, NAV, DT, TPV, EH, EB, MX, AM, PZ, PP, MD, SK, MP, SP, AV, FK, NH, IA, AS, and HP collected data. All authors reviewed and approved the final version of the manuscript.

Corresponding author

Correspondence to Konstantinos Liapis.

Ethics declarations

Competing interests

IK, NAV, AS, and V. Pappa have received research funding from Celgene Corporation for work outside this study. IK, SGP, TPV, AGG, EH, PP, AK, AS, V. Pappa and NAV have received honoraria from Genesis Pharma Hellas S.A. for work outside this study. All other authors: no conflicts of interest.

Ethical approval

This study was approved by the Ethics Committee of the Hellenic Society of Hematology (Protocol: No.8/26-3-2008). This study was done in accordance with the ethical standards of the Institutional Research Committees of the participating centers, and in compliance with the ethical principles of the Declaration of Helsinki.

Informed consent

The basis for this study formed the database of the Hellenic National Registry of Myelodysplastic and Hypoplastic Syndromes (N = 2972 patients) and the database of the ITP Registry of the Hellenic Society of Hematology (N = 1317 patients). All data were collected during routine patient care. This study was approved by the Ethics Committee of the Hellenic Society of Hematology (Protocol: No.8/26-3-2008).

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Liapis, K., Papadopoulos, V., Pontikoglou, C. et al. Myelodysplastic neoplasm with isolated thrombocytopenia and immune thrombocytopenic purpura in adults: insights from a comparison of two national registries. Leukemia 37, 708–711 (2023). https://doi.org/10.1038/s41375-023-01819-x

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