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Multiple myeloma, gammopathies

Improving prognostic assignment in older adults with multiple myeloma using acquired genetic features, clonal hemopoiesis and telomere length

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Fig. 1: The outcome of a range of molecular and clinical features as a function of age.
Fig. 2: The distribution and nature of the mutations used to define clonal hematopoiesis.

References

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Acknowledgements

We thank all the patients and their families for their contributions to this study. The authors acknowledge continued support from Multiple Myeloma Research Foundation and the Perelman Family Foundation. BAW and GJM received grant support through a Translational Research Program award from the Leukemia & Lymphoma Society (6020-20). EMB received funding from the Fédération Française de Recherche sur le Myélome et les Gammapathies under the aegis of the Fondation de France.

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Author notes

  1. These authors contributed equally: Eileen M. Boyle, Louis Williams.

Authors and Affiliations

  1. Myeloma Research Program, Perlmutter Cancer Center, NYU Langone Medical Center, New-York, NY, USA

    Eileen M. Boyle, Louis Williams, Patrick Blaney, Hussein Ghamlouch, Jinyoung Choi, Yubao Wang, Jessica Caro, James H. Stoeckle, Arnaldo Arbini, David Kaminetzky, Marc Braunstein, Benedetto Bruno, Beatrice Razzo, Faith E. Davies & Gareth J. Morgan

  2. Department of Biomedical Informatics, UAMS, Little Rock, AR, USA

    Cody Ashby & Michael Bauer

  3. Division of Hematology Oncology, Indiana University, Indianapolis, IN, USA

    Brian A. Walker

  4. INSERM 1052/CNRS 5286 Cancer Research Center of Lyon, Lyon, France

    Emeline Perrial

  5. Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Benjamin Diamond, Kylee Maclachlan & Francesco Maura

  6. Myeloma Program, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA

    Ola Landgren

  7. Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Rachel Litke

  8. School of Medicine Cardiff University, Cardiff, Wales, United Kingdom

    Christopher D. Fegan

  9. Multiple Myeloma Research Laboratory, TGen, Phoenix, AZ, USA

    Johnathan Keats

  10. MMRF, Norwalk, CT, USA

    Daniel Auclair

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  1. Eileen M. Boyle
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Correspondence to Gareth J. Morgan.

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Boyle, E.M., Williams, L., Blaney, P. et al. Improving prognostic assignment in older adults with multiple myeloma using acquired genetic features, clonal hemopoiesis and telomere length. Leukemia 36, 221–224 (2022). https://doi.org/10.1038/s41375-021-01320-3

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