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Acknowledgements
This work was supported by a Leukemia & Lymphoma Society (LLS) Translational Research Program Award (6086-12) (MWD) and an LLS Specialized Center of Research Program Award (GCNCR0314A-UTAH) (MWD). This work was also supported by the National Institutes of Health (NIH) National Cancer Institute grant R01CA178397 (MWD and TO). CCM was funded by the pediatric cancer program, which is supported by the Intermountain Healthcare and Primary Children’s Hospital Foundations, Department of Pediatrics, Division of Pediatric Hematology/Oncology, and the University of Utah. HT was a visiting scholar from Singapore, and was supported by Research Training Fellowship from National Medical Research Council of Singapore. DY is supported by the International Award from the Lady Tata Memorial Trust following the Special Fellow Award from the LLS. We thank James Marvin, Director of the Flow Cytometry Facility at The University of Utah for assistance with experiments. The University of Utah Flow Cytometry Facility was supported by the National Cancer Institute through award 5P30CA042014-24 and the National Center for Research Resources of the NIH under award 1S10RR026802-01. We acknowledge Cell Imaging Core at the University of Utah for use of equipment and thank Michael J. Bridge, PhD for his assistance in image acquisition.
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HT and MWD conceived the project. HT, ADP. and MWD analyzed the data. HT, ADP, TO, and MWD wrote the manuscript. CCM analyzed the microarray data. HT, ADP, LPB, AME, WLH, DY, and AS performed experiments. SS provided critical reagents. MWD provided clinical information and research materials. PMC prepared the patient samples. ADP, CCM, and TO critically reviewed the manuscript.
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MWD is on the advisory board and is a consultant for Incyte, Novartis and Pfizer, and serves on the advisory board for Takeda, Blueprint and Galena BioPharma. His laboratory receives research funding from Novartis and Pfizer. SS is the President and Chief Scientific Officer of Karyopharm Therapeutics.
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Than, H., Pomicter, A.D., Yan, D. et al. Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells. Leukemia 34, 1679–1683 (2020). https://doi.org/10.1038/s41375-020-0708-1
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DOI: https://doi.org/10.1038/s41375-020-0708-1
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