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Chronic myeloproliferative neoplasms

High circulating levels of MPO-DNA are associated with thrombosis in patients with MPN

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Acknowledgements

We wish to thank Axelle Lascaux, Gabriel Etienne, Jean-François Viallard, Pierre Duffau for their help in patient recruitment. We are grateful to William Vainchenker (Institut Gustave Roussy, Inserm U1009) for helpful discussions. We are grateful to DA Tregouet for discussions about statistical analyses. We are also grateful to the French Intergroup Myeloproliferative (FIM). This study was supported by research grants from INSERM, The Fondation Bettencourt Schueller, Force Hemato. AG was supported by research grant from INSERM (Poste Accueil INSERM) and VGL by ANR-DFG JAKPOT.

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Author notes

  1. These authors contributed equally: Alexandre Guy, Simon Favre

Authors and Affiliations

  1. University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, 33600, Pessac, France

    Alexandre Guy, Simon Favre, Sylvie Labrouche-Colomer, Laure Deloison, Virginie Gourdou-Latyszenok, Marie-Ange Renault, Etienne Riviere & Chloe James

  2. CHU de Bordeaux, Laboratoire d’Hématologie, 33600, Pessac, France

    Sylvie Labrouche-Colomer & Chloe James

  3. CHU de Bordeaux, Service de Médecine Interne, 33600, Pessac, France

    Etienne Riviere

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  1. Alexandre Guy
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  2. Simon Favre
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  3. Sylvie Labrouche-Colomer
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  8. Chloe James
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Contributions

AG and SF contributed to designing and performing experiments, analysis and interpretation of data, and preparing the manuscript. SLC, LD and VGL contributed to designing and performing experiments, analysis and interpretation of data, and preparing the manuscript. MAR contributed to performing experiments, analysis and interpretation of data, and preparing the manuscript. ER contributed to provide patients blood sample and prepare the manuscript. CJ contributed to supervising the study, designing experiments, analysis and interpretation of data, and preparing the manuscript.

Corresponding author

Correspondence to Chloe James.

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Guy, A., Favre, S., Labrouche-Colomer, S. et al. High circulating levels of MPO-DNA are associated with thrombosis in patients with MPN. Leukemia 33, 2544–2548 (2019). https://doi.org/10.1038/s41375-019-0500-2

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