A recent report shows that several 'poly-ADP-ribose-polymerases' may function exclusively as a family of endogenous mono-ADP-ribosyltransferases, providing a new, molecularly less complex and broadened cellular role for this elusive post-translational modification.
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Acknowledgements
K.D. is funded by the European Union FP6 Marie Curie Research and Training Network “Chromatin Plasticity”. S.T. and K.D. are students in the European Molecular Biology Laboratory's International PhD Programme. A.G.L. acknowledges the financial support of the European Molecular Biology Laboratory.
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Till, S., Diamantara, K. & Ladurner, A. PARP: a transferase by any other name. Nat Struct Mol Biol 15, 1243–1244 (2008). https://doi.org/10.1038/nsmb1208-1243
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DOI: https://doi.org/10.1038/nsmb1208-1243
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