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A monkey wrench in the kinase machine

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Last year Zhang, Kuriyan and colleagues demonstrated that an asymmetric dimer interaction between EGF receptor kinase domains is a key element of receptor activation. They now show that a cellular protein that inhibits receptor activity targets this dimer interface, not only uncovering an important regulatory mechanism but also opening a new route to therapeutic kinase inhibition.

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Figure 1: Schematic model of EGFR activation.
Figure 2: Schematic model of inhibition of the EGFR kinase by Mig6.

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Authors and Affiliations

  1. Daniel J. Leahy is in the Department of Biophysics & Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA. dleahy@jhmi.edu,

    Daniel J Leahy

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  1. Daniel J Leahy
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Leahy, D. A monkey wrench in the kinase machine. Nat Struct Mol Biol 14, 1120–1121 (2007). https://doi.org/10.1038/nsmb1207-1120

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