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Wobble during decoding: more than third-position promiscuity

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Structural studies by the Ramakrishnan and Agris groups allow us to directly observe how the ribosome's decoding site accommodates non-Watson-Crick base pairs in the third position of the codon-anticodon triplet while maintaining the one-amino-acid-per-codon framework that is central to life.

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Figure 1: Inosine·adenosine base pair conformations.
Figure 2: Cartoon structures showing the effects of modified nucleotides during decoding.

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  1. Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA

    Luisa Cochella & Rachel Green

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  1. Luisa Cochella
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  2. Rachel Green
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Cochella, L., Green, R. Wobble during decoding: more than third-position promiscuity. Nat Struct Mol Biol 11, 1160–1162 (2004). https://doi.org/10.1038/nsmb1204-1160

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