How can a single protein recognize and bind a variety of partner proteins that vary in sequence and structure? Analysis of the nuclear export receptor CRM1 provides new insight and surprising conclusions.
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References
Güttler, D. et al. Nat. Struct. Mol. Biol. 17, 1367–1376 (2010).
Cook, A., Bono, F., Jinek, M. & Conti, E. Annu. Rev. Biochem. 76, 647–671 (2007).
Görlich, D. & Kutay, U. Annu. Rev. Cell Dev. Biol. 15, 607–660 (1999).
Mattaj, I.W. & Englmeier, L. Annu. Rev. Biochem. 67, 265–306 (1998).
Huber, J. et al. EMBO J. 17, 4114–4126 (1998).
Johnson, A.W., Lund, E. & Dahlberg, J. Trends Biochem. Sci. 27, 580–585 (2002).
Ohno, M., Segref, A., Bachi, A., Wilm, M. & Mattaj, I.W. Cell 101, 187–198 (2000).
Dong, X. et al. Nature 458, 1136–1141 (2009).
Monecke, T. et al. Science 324, 1087–1091 (2009).
la Cour, T. et al. Protein Eng. Des. Sel. 17, 527–536 (2004).
Cook, A.G. & Conti, E. Curr. Opin. Struct. Biol. 20, 247–252 (2010).
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Mattaj, I., Müller, C. Solving the NES problem. Nat Struct Mol Biol 17, 1288–1289 (2010). https://doi.org/10.1038/nsmb1110-1288
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DOI: https://doi.org/10.1038/nsmb1110-1288
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