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Weapons in the molecular arms race

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Flock House virus protein B2 suppresses the RNA-mediated interference response by binding double-stranded RNA of almost any size or sequence. The crystal structure of this protein bound to RNA reveals a novel fold that suggests its mechanism of action.

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Figure 1: The pathway of RNA silencing (RNAi), shown with the proposed mechanisms of B2 and p19 inhibition.
Figure 2: Comparison of the structures of p19, B2 and two dsRBMs bound to their dsRNA targets.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Mail stop 8101, PO Box 6511, Aurora, Colorado, 80045, USA

    Jeffrey S Kieft & Jennifer S Pfingsten

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  1. Jeffrey S Kieft
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  2. Jennifer S Pfingsten
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Kieft, J., Pfingsten, J. Weapons in the molecular arms race. Nat Struct Mol Biol 12, 938–939 (2005). https://doi.org/10.1038/nsmb1105-938

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