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Taking control of G-quadruplexes

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Telomeres are crucial for maintaining the integrity of the genome. Several alternative structures have been proposed for these caps, and understanding their biological significance is a matter of great interest. Probing of native telomeres now reveals that telomere end-binding proteins may control the formation of G-quadruplex DNA in vivo.

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Figure 1: Structures formed by G-rich DNA.
Figure 2: Schematic showing a model mechanism wherein TEBPα-β tethers telomeres to the nuclear matrix and stabilizes G-quadruplex DNA.

References

  1. Cech, T.R. Cell 116, 273–279 (2004).

    Article  CAS  Google Scholar 

  2. Smogorzewska, A. & de Lange, T. Annu. Rev. Biochem. 73, 177–208 (2004).

    Article  CAS  Google Scholar 

  3. Gottschling, D.E. & Zakian, V.A. Cell 47, 195–205 (1986).

    Article  CAS  Google Scholar 

  4. Price, C.M. & Cech, T.R. Genes Dev. 1, 783–793 (1987).

    Article  CAS  Google Scholar 

  5. Paeschke, K., Simonsson, T., Postberg, J., Rhodes, D. & Lipps, H.J. Nat. Struct. Mol. Biol. 12, 847–854 (2005).

    Article  CAS  Google Scholar 

  6. Horvath, M.P., Schweiker, V.L., Bevilacqua, J.M., Ruggles, J.A. & Schultz, S.C. Cell 95, 963–974 (1998).

    Article  CAS  Google Scholar 

  7. Froelich-Ammon, S.J., Dickinson, B.A., Bevilacqua, J.M., Schultz, S.C. & Cech, T.R. Genes Dev. 12, 1504–1514 (1998).

    Article  CAS  Google Scholar 

  8. Jonsson, F., Postberg, J., Schaffitzel, C. & Lipps, H.J. Chromosome Res. 10, 445–453 (2002).

    Article  Google Scholar 

  9. Garvik, B., Carson, M. & Hartwell, L. Mol. Cell. Biol. 15, 6128–6138 (1995).

    Article  CAS  Google Scholar 

  10. Baumann, P. & Cech, T.R. Science 292, 1171–1175 (2001).

    Article  CAS  Google Scholar 

  11. Hockemeyer, D., Sfeir, A.J., Shay, J.W., Wright, W.E. & de Lange, T. EMBO J. 24, 2667–2678 (2005).

    Article  CAS  Google Scholar 

  12. Veldman, T., Etheridge, K.T. & Counter, C.M. Curr. Biol. 14, 2264–2270 (2004).

    Article  CAS  Google Scholar 

  13. Yang, Q., Zheng, Y.L. & Harris, C.C. Mol. Cell. Biol. 25, 1070–1080 (2005).

    Article  CAS  Google Scholar 

  14. Schaffitzel, C. et al. Proc. Natl. Acad. Sci. USA 98, 8572–8577 (2001).

    Article  CAS  Google Scholar 

  15. Fang, G. & Cech, T.R. Cell 74, 875–885 (1993).

    Article  CAS  Google Scholar 

  16. Fang, G., Gray, J.T. & Cech, T.R. Genes Dev. 7, 870–882 (1993).

    Article  CAS  Google Scholar 

  17. Postberg, J. et al. J. Cell Sci. 114, 1861–1866 (2001).

    CAS  PubMed  Google Scholar 

  18. Hicke, B. et al. Nucleic Acids Res. 23, 1887–1893 (1995).

    Article  CAS  Google Scholar 

  19. Mohaghegh, P., Karow, J.K., Brosh, R.M. Jr., Bohr, V.A. & Hickson, I.D. Nucleic Acids Res. 29, 2843–2849 (2001).

    Article  CAS  Google Scholar 

  20. Huber, M.D., Lee, D.C. & Maizels, N. Nucleic Acids Res. 30, 3954–3961 (2002).

    Article  CAS  Google Scholar 

  21. Zaug, A.J., Podell, E.R. & Cech, T.R. Proc. Natl. Acad. Sci. USA 102, 10864–10869 (2005).

    Article  CAS  Google Scholar 

  22. Gellert, M., Lipsett, M.N. & Davies, D.R. Proc. Natl. Acad. Sci. USA 48, 2013–2018 (1962).

    Article  CAS  Google Scholar 

  23. Sundquist, W.I. & Klug, A. Nature 342, 825–829 (1989).

    Article  CAS  Google Scholar 

  24. Williamson, J.R., Raghuraman, M.K. & Cech, T.R. Cell 59, 871–880 (1989).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, 64110, Missouri, USA

    Peter Baumann

  2. Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, 66160, Kansas, USA

    Peter Baumann

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  1. Peter Baumann
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Baumann, P. Taking control of G-quadruplexes. Nat Struct Mol Biol 12, 832–833 (2005). https://doi.org/10.1038/nsmb1005-832

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