Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing.
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Kornblihtt, A., Schor, I., Allo, M. et al. When chromatin meets splicing. Nat Struct Mol Biol 16, 902–903 (2009). https://doi.org/10.1038/nsmb0909-902
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DOI: https://doi.org/10.1038/nsmb0909-902
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