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Signaling degradation

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Many proteins are marked for destruction by covalent attachment of a polyubiquitin chain that directs binding of the modified molecule to the proteasome. A new report demonstrates that an unstructured region of the substrate must also be recognized to begin proteolytic engagement.

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Figure 1: Model for protein degradation by energy-dependent proteases, which consist, at a minimum, of an ATP-dependent unfoldase-translocase and a compartmental peptidase.

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  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Jon A Kenniston & Robert T Sauer

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  1. Jon A Kenniston
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  2. Robert T Sauer
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Kenniston, J., Sauer, R. Signaling degradation. Nat Struct Mol Biol 11, 800–802 (2004). https://doi.org/10.1038/nsmb0904-800

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