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Kill the messenger: bacterial antisense RNA promotes mRNA decay

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Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR.

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Figure 1: MicC: two targets, two mechanisms.

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Authors and Affiliations

  1. E. Gerhart H. Wagner is in the Microbiology Program at the Department of Cell & Molecular Biology, Uppsala University, Uppsala, Sweden. gerhart.wagner@icm.uu.se,

    E Gerhart H Wagner

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  1. E Gerhart H Wagner
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Wagner, E. Kill the messenger: bacterial antisense RNA promotes mRNA decay. Nat Struct Mol Biol 16, 804–806 (2009). https://doi.org/10.1038/nsmb0809-804

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