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Grb-ing hold of insulin signaling

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It is just as important to shut off a signaling pathway as it is to turn it on. A new study on the tandem Ras-associating (RA) and pleckstrin-homology (PH) domains of Grb10 and Grb14 provides important insight into a multicomponent assembly for downregulating insulin receptor signaling.

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Figure 1: Multicomponent assembly for Grb10- and Grb14-mediated inhibition of insulin receptor signaling.

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Authors and Affiliations

  1. Derek F. J. Ceccarelli is in the Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. ceccarelli@lunenfeld.ca,

    Derek F J Ceccarelli

  2. and the Department of Molecular and Medical Genetics, Frank Sicheri is in the Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada. sicheri@lunenfeld.ca,

    Frank Sicheri

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  1. Derek F J Ceccarelli
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  2. Frank Sicheri
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Ceccarelli, D., Sicheri, F. Grb-ing hold of insulin signaling. Nat Struct Mol Biol 16, 803–804 (2009). https://doi.org/10.1038/nsmb0809-803

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