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Blocking HIV-1 virus assembly

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Two recent papers identify the first peptide inhibitor that binds to the structural protein of HIV-1, thereby blocking assembly of both immature and mature virus-like particles in vitro. These studies open the door to a strategy for the development of new therapies against the virus.

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Figure 1: Schematic representation of immature and mature HIV-1 particles.

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Vogt, V. Blocking HIV-1 virus assembly. Nat Struct Mol Biol 12, 638–639 (2005). https://doi.org/10.1038/nsmb0805-638

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