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Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation

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MicroRNAs are small, noncoding RNAs that regulate gene expression in eukaryotes. The multipurpose protein hnRNP A1, a well-known factor in the regulation of precursor messenger RNA splicing, has now been implicated in the biogenesis of the microRNA miR-18a, shedding further light on the emerging topic of post-transcriptional regulation of microRNA expression.

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Figure 1: Proposed functions of hnRNP A1 in post-transcriptional regulation of miRNA expression.

References

  1. Guil, S. & Caceres, J.F. Nat. Struct. Mol. Biol. 14, 591–596 (2007).

    Article  CAS  PubMed  Google Scholar 

  2. Mayeda, A. & Krainer, A.R. Cell 68, 365–375 (1992).

    Article  CAS  PubMed  Google Scholar 

  3. Caceres, J.F. & Kornblihtt, A.R. Trends Genet. 18, 186–193 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Krecic, A.M. & Swanson, M.S. Curr. Opin. Cell Biol. 11, 363–371 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Pinol-Roma, S. & Dreyfuss, G. Nature 355, 730–732 (1992).

    Article  CAS  PubMed  Google Scholar 

  6. Bonnal, S. et al. J. Biol. Chem. 280, 4144–4153 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Hamilton, B.J., Burns, C.M., Nichols, R.C. & Rigby, W.F. J. Biol. Chem. 272, 28732–28741 (1997).

    Article  CAS  PubMed  Google Scholar 

  8. LaBranche, H. et al. Nat. Genet. 19, 199–202 (1998).

    Article  CAS  PubMed  Google Scholar 

  9. Lee, Y., Jeon, K., Lee, J.T., Kim, S. & Kim, V.N. EMBO J. 21, 4663–4670 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lee, Y. et al. Nature 425, 415–419 (2003).

    Article  CAS  PubMed  Google Scholar 

  11. Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E. & Kutay, U. Science 303, 95–98 (2004).

    Article  CAS  PubMed  Google Scholar 

  12. Yi, R., Qin, Y., Macara, I.G. & Cullen, B.R. Genes Dev. 17, 3011–3016 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bernstein, E., Caudy, A.A., Hammond, S.M. & Hannon, G.J. Nature 409, 363–366 (2001).

    Article  CAS  PubMed  Google Scholar 

  14. Hutvágner, G., McLachlan, J., Bálint, É., Tuschl, T. & Zamore, P.D. Science 293, 834–838 (2001).

    Article  PubMed  Google Scholar 

  15. Kloosterman, W.P. & Plasterk, R.H. Dev. Cell 11, 441–450 (2006).

    Article  CAS  PubMed  Google Scholar 

  16. Lewis, B.P., Burge, C.B. & Bartel, D.P. Cell 120, 15–20 (2005).

    Article  CAS  PubMed  Google Scholar 

  17. Rodriguez, A., Griffiths-Jones, S., Ashurst, J.L. & Bradley, A. Genome Res. 14, 1902–1910 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Kim, Y.K. & Kim, V.N. EMBO J. 26, 775–783 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Pontius, B.W. & Berg, P. J. Biol. Chem. 267, 13815–13818 (1992).

    CAS  PubMed  Google Scholar 

  20. Hanamura, A., Caceres, J.F., Mayeda, A., Franza, B.R., Jr. & Krainer, A.R. RNA 4, 430–444 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank K. Heindl and S. Weitzer for critically reading the manuscript.

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Authors and Affiliations

  1. Anne Færch Nielsen is in the Department of Molecular Biology, University of Aarhus, CF Møllers Allé 1130, 8000 Aarhus C, Denmark,

    Anne Færch Nielsen

  2. Philipp J. F. Leuschner and Javier Martinez are at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, 1030, Vienna, Austria. javier.martinez@imba.oeaw.ac.at,

    Philipp J F Leuschner & Javier Martinez

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  1. Anne Færch Nielsen
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Nielsen, A., Leuschner, P. & Martinez, J. Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation. Nat Struct Mol Biol 14, 572–573 (2007). https://doi.org/10.1038/nsmb0707-572

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