Covalent modifications of histones play an important role in regulating chromatin structure and function, probably by serving as docking sites for effector proteins. The discovery that PHD fingers of two different proteins recognize trimethyl-Lys4 of histone H3 supports and extends this notion.
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Zhang, Y. It takes a PHD to interpret histone methylation. Nat Struct Mol Biol 13, 572–574 (2006). https://doi.org/10.1038/nsmb0706-572
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DOI: https://doi.org/10.1038/nsmb0706-572
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