Skip to main content
SpringerLink
Log in

RNA allostery glimpsed

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Riboswitches provide an elegantly simple means of coupling metabolic sensing to genetic regulation. Recent work provides a wealth of structural insight into ligand binding by these RNAs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Genetic mechanisms of metabolite-sensing regulatory RNAs.
Figure 2: TPP- and SAM-sensing RNAs used in crystallography.
Figure 3: Common architecture for TPP switches.
Figure 4: Antiterminator sequestration in the TPP and SAM sensors.

References

  1. Nudler, E. & Mironov, A.S. Trends Biochem. Sci. 29, 11–17 (2004).

    Article  CAS  Google Scholar 

  2. Winkler, W.C. & Breaker, R.R. Annu. Rev. Microbiol. 59, 487–517 (2005).

    Article  CAS  Google Scholar 

  3. Jansen, J.A., McCarthy, T.J., Soukup, G.A. & Soukup, J.K. Nat. Struct. Mol. Biol. 13, 517–523 (2006).

    Article  CAS  Google Scholar 

  4. Montange, R.K. & Batey, R.T. Nature, advance online publication 28 Jun 2006 (doi:10.1038/nature04819).

  5. Serganov, A, Polonskaia, A, Phan, AT, Breaker, RR, Patel, DJ . Nature, advance online publication 21 May 2006 (doi:10.1038/nature04740).

  6. Thore, S., Leibundgut, M. & Ban, N. Science 312, 1208–1211 (2006).

    Article  CAS  Google Scholar 

  7. Vicens, Q. & Cech, T.R. Trends Biochem. Sci. 31, 41–51 (2006).

    Article  CAS  Google Scholar 

  8. Sudarsan, N., Cohen-Chalamish, S., Nakamura, S., Emilsson, G.M. & Breaker, R.R. Chem. Biol. 12, 1325–1335 (2005).

    Article  CAS  Google Scholar 

  9. Winkler, W.C., Nahvi, A. & Breaker, R.R. Nature 419, 952–956 (2002).

    Article  CAS  Google Scholar 

  10. McDaniel, B.A., Grundy, F.J. & Henkin, T.M. Mol. Microbiol. 57, 1008–1021 (2005).

    Article  CAS  Google Scholar 

  11. Gilbert, S.D., Stoddard, C.D., Wise, S.J. & Batey, R.T. J. Mol. Biol. 359, 754–768 (2006).

    Article  CAS  Google Scholar 

  12. Cromie, M.J., Shi, Y., Latifi, T. & Groisman, E.A. Cell 125, 71–84 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390-9038, Texas, USA

    Wade C Winkler & Charles E Dann III

Authors
  1. Wade C Winkler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles E Dann III
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Winkler, W., Dann, C. RNA allostery glimpsed. Nat Struct Mol Biol 13, 569–571 (2006). https://doi.org/10.1038/nsmb0706-569

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0706-569

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation