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Endo-siRNAs: yet another layer of complexity in RNA silencing

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Organisms possessing RNA-dependent RNA polymerase activity are known to produce endogenous small interfering RNAs (esiRNAs). It had been thought that organisms such as flies and mammals lacking this activity would not produce esiRNAs. However, it has now been shown that a functional esiRNA pathway is present in such animals; the esiRNAs are derived from a variety of endogenous double-stranded RNA substrates.

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Figure 1: Sources of endogenous double-stranded RNAs.

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Authors and Affiliations

  1. Timothy W. Nilsen is at the Center for RNA Molecular Biology and Department of Biochemistry, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4973, USA. twn@case.edu,

    Timothy W Nilsen

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  1. Timothy W Nilsen
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Nilsen, T. Endo-siRNAs: yet another layer of complexity in RNA silencing. Nat Struct Mol Biol 15, 546–548 (2008). https://doi.org/10.1038/nsmb0608-546

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