The solution structures of multiple forms of the adaptor protein CRK show how its domains fit together, providing insight into the autoregulation and ligand-mediated regulation of CRK.
Accession codes
References
Kobashigawa, Y. et al. Nat. Struct. Mol. Biol. 14, 503–510 (2007).
Mayer, B.J., Hamaguchi, M. & Hanafusa, H. Nature 332, 272–275 (1988).
Feller, S.M. Oncogene 20, 6348–6371 (2001).
Rodrigues, S.P. et al. Mol. Cancer Res. 3, 183–194 (2005).
Linghu, H. et al. Oncogene 25, 3547–3556 (2006).
Knudsen, B.S. et al. EMBO J. 14, 2191–2198 (1995).
Feller, S.M. & Lewitzky, M. Curr. Pharm. Des. 12, 529–548 (2006).
Feller, S.M., Knudsen, B. & Hanafusa, H. EMBO J. 13, 2341–2351 (1994).
Sarkar, P., Reichman, C., Saleh, T., Birge, R.B. & Kalodimos, C.G. Mol. Cell 25, 413–426 (2007).
Harkiolaki, M., Gilbert, R.J., Jones, E.Y. & Feller, S.M. Structure 14, 1741–1753 (2006).
Pickford, A.R. & Campbell, I.D. Chem. Rev. 104, 3557–3565 (2004).
Bax, A. & Grishaev, A. Curr. Opin. Struct. Biol. 15, 563–570 (2005).
Fushman, D., Varadan, R., Assfalg, M. & Walker, O. Prog. Nucl. Magn. Reson. Spectrosc. 44, 189–214 (2004).
Lipfert, J. & Doniach, S. Annu. Rev. Biophys. Biomol. Struct. 36, 307–327 (2007).
Brazin, K.N., Mallis, R.J., Fulton, D.B. & Andreotti, A.H. Proc. Natl. Acad. Sci. USA 99, 1899–1904 (2002).
Smith, J.J. et al. Mol. Cell. Biol. 22, 1412–1423 (2002).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Cowburn, D. Moving parts: how the adaptor protein CRK is regulated, and regulates. Nat Struct Mol Biol 14, 465–466 (2007). https://doi.org/10.1038/nsmb0607-465
Issue Date:
DOI: https://doi.org/10.1038/nsmb0607-465
- Springer Nature America, Inc.
This article is cited by
-
Tuning protein autoinhibition by domain destabilization
Nature Structural & Molecular Biology (2011)
-
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Cell Communication and Signaling (2009)