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Making structural sense of nonsense-mediated decay

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A new study reports the hUpf2-hUpf3b interaction domain structure and provides the first structural insight into the core of the nonsense-mediated decay pathway. Surprisingly, the RNA-recognition motif of hUpf3b, a domain typically involved in RNA binding, constitutes instead an interaction surface for hUpf2.

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Figure 1: Human Upf proteins hUpf1, hUpf2 and the two hUpf3 paralogs, hUpf3a and hUpf3b.
Figure 2: A current model for NMD in mammalian cells.

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  1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309, Colorado, USA

    Jens Lykke-Andersen

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  1. Jens Lykke-Andersen
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Lykke-Andersen, J. Making structural sense of nonsense-mediated decay. Nat Struct Mol Biol 11, 305–306 (2004). https://doi.org/10.1038/nsmb0404-305

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