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Two new crystal structures of ubiquitin (Ub) in complex with fragments of the endosomal proteins Rabex-5 and HRS show intriguing new modes of Ub binding and reveal that both fragments can bind two Ub molecules simultaneously.

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Figure 1: Crystal structures and key intermolecular contacts in the HRS– and Rabex-5–Ub complexes.

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Authors and Affiliations

  1. Department of Biochemistry at the University of Utah, Salt Lake City, 84112-5650, Utah, USA

    Steven L Alam & Wesley I Sundquist

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  1. Steven L Alam
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  2. Wesley I Sundquist
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Alam, S., Sundquist, W. U2. Nat Struct Mol Biol 13, 186–188 (2006). https://doi.org/10.1038/nsmb0306-186

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