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Tip20p reaches out to Dsl1p to tether membranes

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Large, multisubunit complexes have been implicated in tethering transport vesicles to organelle membranes before membrane fusion. New structures add to the growing list of tethering complexes that contain conserved helical bundle structures and provide a first glimpse of how these complexes are assembled.

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Figure 1: The Dsl1p complex subunits have similar helical bundle structures to those of the exocyst and COG complexes, whereas the TRAPP I complex is structurally distinct.

Kim Caesar

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Authors and Affiliations

  1. Mary Munson is in the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. mary.munson@umassmed.edu,

    Mary Munson

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  1. Mary Munson
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Munson, M. Tip20p reaches out to Dsl1p to tether membranes. Nat Struct Mol Biol 16, 100–102 (2009). https://doi.org/10.1038/nsmb0209-100

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