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Energizing type III secretion machines: what is the fuel?

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Bacterial type III secretion machines have adapted to carry out numerous functions, ranging from locomotion to protein delivery into nucleated cells. One of the most intriguing issues is the source of energy that fuels their activities. Despite recent advances, there are still many questions to be resolved.

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Figure 1: Model for the energizing of type III secretion machines.

Kim Caesar

References

  1. Galan, J.E. & Wolf-Watz, H. Nature 444, 567–573 (2006).

    Article  CAS  Google Scholar 

  2. Cornelis, G.R. Nat. Rev. Microbiol. 4, 811–825 (2006).

    Article  CAS  Google Scholar 

  3. Aizawa, S.I. FEMS Microbiol. Lett. 202, 157–164 (2001).

    Article  CAS  Google Scholar 

  4. Feldman, M.F. & Cornelis, G.R. FEMS Microbiol. Lett. 219, 151–158 (2003).

    Article  CAS  Google Scholar 

  5. Bennett, J.C. & Hughes, C. Trends Microbiol. 8, 202–204 (2000).

    Article  CAS  Google Scholar 

  6. Bar Tana, J., Howlett, B. & Koshland, D.J. J. Bacteriol. 130, 787–792 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Galperin, M., Dibrov, P. & Glagolev, A. FEBS Lett. 143, 319–322 (1982).

    Article  CAS  Google Scholar 

  8. Wilharm, G. et al. Infect. Immun. 72, 4004–4009 (2004).

    Article  CAS  Google Scholar 

  9. de Keyzer, J., van der Does, C. & Driessen, A. Cell. Mol. Life Sci. 60, 2034–2052 (2003).

    Article  CAS  Google Scholar 

  10. Vogler, A.P., Homma, M., Irikura, V.M. & Macnab, R.M. J. Bacteriol. 173, 3564–3572 (1991).

    Article  CAS  Google Scholar 

  11. Dreyfus, G., Williams, A.W., Kawagishi, I. & Macnab, R.M. J. Bacteriol. 175, 3131–3138 (1993).

    Article  CAS  Google Scholar 

  12. Eichelberg, K., Ginocchio, C. & Galán, J.E. J. Bacteriol. 176, 4501–4510 (1994).

    Article  CAS  Google Scholar 

  13. Woestyn, S., Allaoui, A., Wattiau, P. & Cornelis, G.R. J. Bacteriol. 176, 1561–1569 (1994).

    Article  CAS  Google Scholar 

  14. Fan, F. & Macnab, R.M. J. Biochem. 271, 31981–31988 (1996).

    CAS  Google Scholar 

  15. Thomas, J., Stafford, G. & Hughes, C. Proc. Natl. Acad. Sci. USA 101, 3945–3950 (2004).

    Article  CAS  Google Scholar 

  16. Gauthier, A. & Finlay, B.B. J. Bacteriol. 185, 6747–6755 (2003).

    Article  CAS  Google Scholar 

  17. Akeda, Y. & Galan, J.E. Nature 437, 911–915 (2005).

    Article  CAS  Google Scholar 

  18. Sorg, J., Blaylock, B. & Schneewind, O. Proc. Natl. Acad. Sci. USA 103, 16490–16495 (2006).

    Article  CAS  Google Scholar 

  19. Minamino, T. & Namba, K. Nature 451, 485–488 (2008).

    Article  CAS  Google Scholar 

  20. Koushik, P., Erhardt, M., Hirano, T., Blair, D.F. & Hughes, K.T. Nature 451, 489–492 (2008).

    Article  Google Scholar 

  21. Baker, T.A. & Sauer, R. Trends Biochem. Sci. 31, 647–653 (2006).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I would like to thank J. Kato and M. Lara-Tejero for useful suggestions and critical reading of this manuscript. Work in the Galán laboratory is supported by grants from the US National Institutes of Health.

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Authors and Affiliations

  1. Jorge E. Galán is at the Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA. jorge.galan@yale.edu,

    Jorge E. Galán

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Galán, J. Energizing type III secretion machines: what is the fuel?. Nat Struct Mol Biol 15, 127–128 (2008). https://doi.org/10.1038/nsmb0208-127

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