Selenocysteinyl-tRNASec is used by many organisms from all three domains of life to incorporate selenocysteine (Sec) site-specifically into certain proteins. Two recent reports have identified a new Sec synthase that catalyzes the last step in the generation of this aminoacyl-tRNA in eukarya and archaea.
References
Bock, A. et al. Mol. Microbiol. 5, 515–520 (1991).
Boyington, J.C., Gladyshev, V.N., Khangulov, S.V., Stadtman, T.C. & Sun, P.D. Science 275, 1305–1308 (1997).
Raaijmakers, H.C. & Romao, M.J. J. Biol. Inorg. Chem. 11, 849–854 (2006).
Bock, A., Thanbichler, M., Rother, M. & Resch, A. in Aminoacyl-tRNA Synthetases (eds. Ibba, M., Francklyn, C.S. & Cusack, S.) 320–327 (Landes Biosciences, Georgetown, Texas, USA, 2005).
Xu, X.M. et al. PLoS Biol. 5, e4 (2006).
Yuan, J. et al. Proc. Natl. Acad. Sci. USA 103, 18923–18927 (2006).
Leinfelder, W., Zehelein, E., Mandrand-Berthelot, M.A. & Bock, A. Nature 331, 723–725 (1988).
Forchhammer, K., Leinfelder, W., Boesmiller, K., Veprek, B. & Bock, A. J. Biol. Chem. 266, 6318–6323 (1991).
Bilokapic, S., Korencic, D., Soll, D. & Weygand-Durasevic, I. Eur. J. Biochem. 271, 694–702 (2004).
Wu, X.Q. & Gross, H.J. Nucleic Acids Res. 21, 5589–5594 (1993).
Kaiser, J.T. et al. Biochemistry 44, 13315–13327 (2005).
Carlson, B.A. et al. Proc. Natl. Acad. Sci. USA 101, 12848–12853 (2004).
Sauerwald, A. et al. Science 307, 1969–1972 (2005).
Gelpi, C., Sontheimer, E.J. & Rodriguez-Sanchez, J.L. Proc. Natl. Acad. Sci. USA 89, 9739–9743 (1992).
Kernebeck, T., Lohse, A.W. & Grotzinger, J. Hepatology 34, 230–233 (2001).
Leinfelder, W., Forchhammer, K., Veprek, B., Zehelein, E. & Bock, A. Proc. Natl. Acad. Sci. USA 87, 543–547 (1990).
Forchhammer, K. & Bock, A. J. Biol. Chem. 266, 6324–6328 (1991).
Feng, L. et al. in Aminoacyl-tRNA Synthetases (eds. Ibba, M., Francklyn, C.S. & Cusack, S.) 314–319 (Landes Biosciences, Georgetown, Texas, USA, 2005).
Krzycki, J.A. Curr. Opin. Microbiol. 8, 706–712 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Hendrickson, T. Easing selenocysteine into proteins. Nat Struct Mol Biol 14, 100–101 (2007). https://doi.org/10.1038/nsmb0207-100
Issue Date:
DOI: https://doi.org/10.1038/nsmb0207-100
- Springer Nature America, Inc.
This article is cited by
-
Dietary selenium regulation of transcript abundance of selenoprotein N and selenoprotein W in chicken muscle tissues
BioMetals (2012)
-
The Expression of Chicken Selenoprotein W, Selenocysteine-synthase (SecS), and Selenophosphate Synthetase-1 (SPS-1) in CHO-K1 Cells
Biological Trace Element Research (2012)
-
Dietary Selenium Affects Selenoprotein W Gene Expression in the Liver of Chicken
Biological Trace Element Research (2011)