DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.
This is a preview of subscription content, log in via an institution to check access.
Kim Caesar
Kim Caesar
References
Huen, M.S. et al. Cell 131, 901–914 (2007).
Kolas, N.K. et al. Science 318, 1637–1640 (2007).
Mailand, N. et al. Cell 131, 887–900 (2007).
Wang, B. & Elledge, S.J. Proc. Natl. Acad. Sci. USA, published online 5 December 2007 (doi:10.1073/pnas.0710061104).
Matsuoka, S. et al. Science 316, 1160–1166 (2007).
Stucki, M. & Jackson, S.P. DNA Repair (Amst.) 5, 534–543 (2006).
Morris, J.R. & Solomon, E. Hum. Mol. Genet. 13, 807–817 (2004).
Polanowska, J., Martin, J.S., Garcia-Muse, T., Petalcorin, M.I. & Boulton, S.J. EMBO J. 25, 2178–2188 (2006).
Ruffner, H., Joazeiro, C.A., Hemmati, D., Hunter, T. & Verma, I.M. Proc. Natl. Acad. Sci. USA 98, 5134–5139 (2001).
Zhao, G.Y. et al. Mol. Cell 25, 663–675 (2007).
Sobhian, B. et al. Science 316, 1198–1202 (2007).
Liu, Z., Wu, J. & Yu, X. Nat. Struct. Mol. Biol. 14, 716–720 (2007).
Kim, H., Chen, J. & Yu, X. Science 316, 1202–1205 (2007).
Wang, B. et al. Science 316, 1194–1198 (2007).
Bekker-Jensen, S. et al. J. Cell Biol. 173, 195–206 (2006).
Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. & Lukas, J. J. Cell Biol. 170, 201–211 (2005).
Durocher, D. et al. Mol. Cell 6, 1169–1182 (2000).
Plans, V. et al. J. Cell. Biochem. 97, 572–582 (2006).
Bergink, S. et al. Genes Dev. 20, 1343–1352 (2006).
Pickart, C.M. & Fushman, D. Curr. Opin. Chem. Biol. 8, 610–616 (2004).
Bothos, J., Summers, M.K., Venere, M., Scolnick, D.M. & Halazonetis, T.D. Oncogene 22, 7101–7107 (2003).
Ito, K. et al. Eur. J. Biochem. 268, 2725–2732 (2001).
Nicassio, F. et al. Curr. Biol. 17, 1972–1977 (2007).
Chen, X., Arciero, C.A., Wang, C., Broccoli, D. & Godwin, A.K. Cancer Res. 66, 5039–5046 (2006).
Dong, Y. et al. Mol. Cell 12, 1087–1099 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bennett, E., Harper, J. DNA damage: ubiquitin marks the spot. Nat Struct Mol Biol 15, 20–22 (2008). https://doi.org/10.1038/nsmb0108-20
Issue Date:
DOI: https://doi.org/10.1038/nsmb0108-20
- Springer Nature America, Inc.
This article is cited by
-
UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis
Cell Death & Disease (2023)
-
E3 ubiquitin ligases in nasopharyngeal carcinoma and implications for therapies
Journal of Molecular Medicine (2023)
-
Ubiquitination by HUWE1 in tumorigenesis and beyond
Journal of Biomedical Science (2018)
-
E3 ubiquitin ligases in cancer and implications for therapies
Cancer and Metastasis Reviews (2017)
-
Histone modifications in DNA damage response
Science China Life Sciences (2016)