In mammals, a soluble bicarbonate-regulated adenylyl cyclase is required for sperm fertility. Crystal structures of a cyanobacterial cousin provide new insights into the molecular mechanisms of activation and catalysis in soluble adenylyl cyclase and other class III nucleotidyl cyclases.
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Tesmer, J. A seminal study of soluble adenylyl cyclase. Nat Struct Mol Biol 12, 7–8 (2005). https://doi.org/10.1038/nsmb0105-7
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DOI: https://doi.org/10.1038/nsmb0105-7
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