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A glimpse into the C-type-inactivated state for a Potassium Channel

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C-type inactivation is a process by which ion flux through a voltage-gated K+ channel is regulated at the selectivity filter. A recent structure of the Kv1.2 channel provides a view into the structural changes of the selectivity filter during C-type inactivation.

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Figure 1: Inactivation in a voltage-gated K+ channel.
Figure 2: The K+-channel selectivity filter.

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Acknowledgements

Research in my laboratory is supported by a grant from the NIH (GM087546).

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  1. the Department of Physiology and Pharmacology, Program in Chemical Biology, Oregon Health & Science University, Portland, Oregon

    Francis I Valiyaveetil

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  1. Francis I Valiyaveetil
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Correspondence to Francis I Valiyaveetil.

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Valiyaveetil, F. A glimpse into the C-type-inactivated state for a Potassium Channel. Nat Struct Mol Biol 24, 787–788 (2017). https://doi.org/10.1038/nsmb.3480

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