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A glimpse into chromatin remodeling

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Chromatin remodelers are ATP-driven enzymes that can slide nucleosomes along DNA. Chen and colleagues present a tantalizing ∼4-Å view of the SWI/SNF ATPase motor bound to the nucleosome, which offers novel structural clues into the remodeling process.

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Figure 1: Remodeler ATPases bind to the internal SHL2 site on the nucleosome.
Figure 2: Nucleosomal DNA contacts made by the SWI/SNF ATPase motor.

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Acknowledgements

The authors acknowledge support from the Wellcome Trust and Cancer Research UK (D.B.W.) and the US National Institutes of Health (R01GM-084192 to G.D.B.).

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Authors and Affiliations

  1. Department of Medicine, Section of Structural Biology, Imperial College London, London, UK

    Dale B Wigley

  2. T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA

    Gregory D Bowman

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  1. Dale B Wigley
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  2. Gregory D Bowman
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Correspondence to Dale B Wigley or Gregory D Bowman.

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Wigley, D., Bowman, G. A glimpse into chromatin remodeling. Nat Struct Mol Biol 24, 498–500 (2017). https://doi.org/10.1038/nsmb.3415

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