Unlike in animals in which gastrulation marks the onset of zygotic transcription and a transition from random to site-specific localization of replication origins, transcription and origin specification in Caenorhabditis elegans are in place before gastrulation. Nonetheless, origin-site redistribution takes place after gastrulation, and is coordinated with changes in the sites of active transcription.
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Sasaki, T., Gilbert, D. Unearthing worm replication origins. Nat Struct Mol Biol 24, 195–196 (2017). https://doi.org/10.1038/nsmb.3385
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DOI: https://doi.org/10.1038/nsmb.3385
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