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Translocation: lights, camera, and action

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The fundamental mechanics of how EF-G catalyzes translocation of the mRNA and tRNA pairs on the ribosome has been intensely studied for over three decades. Two kinetic studies now reveal the sequence of events and the timing of key conformational changes in the ribosome during translocation and identify new intermediates in this complex process.

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Figure 1: Simplified model for translocation.

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Authors and Affiliations

  1. Xinying Shi and Simpson Joseph are at the Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.,

    Xinying Shi & Simpson Joseph

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  1. Xinying Shi
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  2. Simpson Joseph
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Correspondence to Simpson Joseph.

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Shi, X., Joseph, S. Translocation: lights, camera, and action. Nat Struct Mol Biol 23, 367–368 (2016). https://doi.org/10.1038/nsmb.3219

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