Skip to main content
SpringerLink
Log in

Molecular basis of HSF regulation

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Two structural studies provide new insights into the mechanisms regulating the DNA binding and activation of human HSF family members.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Secondary structures and key residues of the human HSF1 DNA-binding domain.
Figure 2: Topology of the DBD and HR-A/B in human HSF1 bound to DNA.

References

  1. Balch, W.E., Morimoto, R.I., Dillin, A. & Kelly, J.W. Science 319, 916–919 (2008).

    Article  CAS  Google Scholar 

  2. Morimoto, R.I. Cold Spring Harb. Symp. Quant. Biol. 76, 91–99 (2011).

    Article  CAS  Google Scholar 

  3. Wolff, S., Weissman, J.S. & Dillin, A. Cell 157, 52–64 (2014).

    Article  CAS  Google Scholar 

  4. Hipp, M.S., Park, S.H. & Hartl, F.U. Trends Cell Biol. 24, 506–514 (2014).

    Article  CAS  Google Scholar 

  5. Akerfelt, M., Morimoto, R.I. & Sistonen, L. Nat. Rev. Mol. Cell Biol. 11, 545–555 (2010).

    Article  CAS  Google Scholar 

  6. Miozzo, F., Sabéran-Djoneidi, D. & Mezger, V. J. Mol. Biol. 427, 3793–3816 (2015).

    Article  CAS  Google Scholar 

  7. Nakai, A. Heat Shock Factor (Springer Japan, 2016).

    Book  Google Scholar 

  8. Mendillo, M.L. et al. Cell 150, 549–562 (2012).

    Article  CAS  Google Scholar 

  9. Vihervaara, A. et al. Proc. Natl. Acad. Sci. USA 110, E3388–E3397 (2013).

    Article  CAS  Google Scholar 

  10. Takii, R. et al. Mol. Cell. Biol. 35, 11–25 (2015).

    Article  Google Scholar 

  11. Neudegger, T., Verghese, J., Hayer-Hartl, M., Hartl, F.U. & Bracher, A. Nat. Struct. Mol. Biol. 23, 140–146 (2016).

    Article  CAS  Google Scholar 

  12. Jaeger, A.M., Pemble, C.W. IV, Sistonen, L. & Thiele, D.J. Nat. Struct. Mol. Biol. 23, 147–154 (2016).

    Article  CAS  Google Scholar 

  13. Littlefield, O. & Nelson, H.C. Nat. Struct. Biol. 6, 464–470 (1999).

    Article  CAS  Google Scholar 

  14. Inouye, S. et al. Mol. Cell. Biol. 23, 5882–5895 (2003).

    Article  CAS  Google Scholar 

  15. Westerheide, S.D., Anckar, J., Stevens, S.M. Jr., Sistonen, L. & Morimoto, R.I. Science 323, 1063–1066 (2009).

    Article  CAS  Google Scholar 

  16. Raychaudhuri, S. et al. Cell 156, 975–985 (2014).

    Article  CAS  Google Scholar 

  17. Ghosh, S.K., Missra, A. & Gilmour, D.S. Mol. Cell. Biol. 31, 4232–4243 (2011).

    Article  CAS  Google Scholar 

  18. Yao, J., Munson, K.M., Webb, W.W. & Lis, J.T. Nature 442, 1050–1053 (2006).

    Article  CAS  Google Scholar 

  19. Gajiwala, K.S. & Burley, S.K. Curr. Opin. Struct. Biol. 10, 110–116 (2000).

    Article  CAS  Google Scholar 

  20. Fujimoto, M. et al. Mol. Cell 48, 182–194 (2012).

    Article  CAS  Google Scholar 

  21. Anckar, J. et al. Mol. Cell. Biol. 26, 955–964 (2006).

    Article  CAS  Google Scholar 

  22. Tateishi, Y. et al. J. Biol. Chem. 284, 2435–2447 (2009).

    Article  CAS  Google Scholar 

  23. Kroeger, P.E. & Morimoto, R.I. Mol. Cell. Biol. 14, 7592–7603 (1994).

    Article  CAS  Google Scholar 

  24. Tan, K. et al. Nat. Commun. 6, 6580 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Akira Nakai is at the Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan.,

    Akira Nakai

Authors
  1. Akira Nakai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akira Nakai.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nakai, A. Molecular basis of HSF regulation. Nat Struct Mol Biol 23, 93–95 (2016). https://doi.org/10.1038/nsmb.3165

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.3165

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation