How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.
References
Dunlap, J.C. Cell 96, 271–290 (1999).
Xu, H. et al. Nat. Struct. Mol. Biol. 22, 476–484 (2015).
Crane, B.R. & Young, M.W. Annu. Rev. Biochem. 83, 191–219 (2014).
Okano, T., Sasaki, M. & Fukada, Y. Neurosci. Lett. 300, 111–114 (2001).
Shearman, L.P. et al. Science 288, 1013–1019 (2000).
Chaves, I. et al. Annu. Rev. Plant Biol. 62, 335–364 (2011).
Huang, N. et al. Science 337, 189–194 (2012).
Schmalen, I. et al. Cell 157, 1203–1215 (2014).
Ye, R. et al. Genes Dev. 28, 1989–1998 (2014).
Hirota, T. et al. Science 337, 1094–1097 (2012).
Kim, J.K. & Forger, D.B. Mol. Syst. Biol. 8, 630 (2012).
Lee, C., Etchegaray, J.P., Cagampang, F.R., Loudon, A.S. & Reppert, S.M. Cell 107, 855–867 (2001).
Stratmann, M., Stadler, F., Tamanini, F., van der Horst, G.T. & Ripperger, J.A. Genes Dev. 24, 1317–1328 (2010).
Wells, M. et al. Proc. Natl. Acad. Sci. USA 105, 5762–5767 (2008).
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Hui, K., Ripperger, J. Grab the wiggly tail: new insights into the dynamics of circadian clocks. Nat Struct Mol Biol 22, 435–436 (2015). https://doi.org/10.1038/nsmb.3039
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DOI: https://doi.org/10.1038/nsmb.3039
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