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A bumpy road for RNA polymerase II

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The identification of a second regulatory checkpoint controlling RNA polymerase II elongation near the poly(A) site of protein-coding genes reveals an additional level of complexity in the modulation of eukaryotic transcriptional elongation and termination.

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Figure 1: RNA polymerase II on the road.

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Authors and Affiliations

  1. Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET) and Departamento de Fisiología, Luciana E. Giono and Alberto R. Kornblihtt are at the Instituto de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.,

    Luciana E Giono & Alberto R Kornblihtt

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  1. Luciana E Giono
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  2. Alberto R Kornblihtt
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Correspondence to Alberto R Kornblihtt.

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The authors declare no competing financial interests.

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Giono, L., Kornblihtt, A. A bumpy road for RNA polymerase II. Nat Struct Mol Biol 22, 353–355 (2015). https://doi.org/10.1038/nsmb.3020

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