Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.
References
Koike, N. et al. Science 338, 349–354 (2012).
Masri, S. & Sassone-Corsi, P. Nat. Rev. Neurosci. 14, 69–75 (2013).
Doi, M., Hirayama, J. & Sassone-Corsi, P. Cell 125, 497–508 (2006).
Nakahata, Y. et al. Cell 134, 329–340 (2008).
Katada, S. & Sassone-Corsi, P. Nat. Struct. Mol. Biol. 17, 1414–1421 (2010).
Aguilar-Arnal, L., Katada, S., Orozco-Solis, R. & Sassone-Corsi, P. Nat. Struct. Mol. Biol. 22, 312–318 (2015).
Schibler, U. & Sassone-Corsi, P. Cell 111, 919–922 (2002).
Maury, E., Ramsey, K.M. & Bass, J. Circ. Res. 106, 447–462 (2010).
Eckel-Mahan, K.L. et al. Cell 155, 1464–1478 (2013).
Chang, H.C. & Guarente, L. Trends Endocrinol. Metab. 25, 138–145 (2014).
Chang, H.C. & Guarente, L. Cell 153, 1448–1460 (2013).
Masri, S. et al. Cell 158, 659–672 (2014).
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Science 324, 654–657 (2009).
Ramsey, K.M. et al. Science 324, 651–654 (2009).
Krivtsov, A.V. & Armstrong, S.A. Nat. Rev. Cancer 7, 823–833 (2007).
Cheng, H.L. et al. Proc. Natl. Acad. Sci. USA 100, 10794–10799 (2003).
McMahon, K.A. et al. Cell Stem Cell 1, 338–345 (2007).
Lim, D.A. et al. Nature 458, 529–533 (2009).
Ma, C.Y. et al. Development 141, 4697–4709 (2014).
Ryall, J.G. et al. Cell Stem Cell 16, 171–183 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Tasselli, L., Chua, K. Methylation gets into rhythm with NAD+-SIRT1. Nat Struct Mol Biol 22, 275–277 (2015). https://doi.org/10.1038/nsmb.3004
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.3004
- Springer Nature America, Inc.