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Yeast cells display synchronized oscillation between phases of high and low oxygen consumption accompanied by a program of cyclical gene expression. A study monitoring mRNA levels, histone modifications and chromatin occupancy of histone modifiers during the yeast metabolic cycle (YMC) at high temporal resolution reveals both 'just-in-time' supply of YMC gene products and new patterns of chromatin reconfiguration associated with transcriptional regulation.

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Figure 1: The yeast metabolic cycle.
Figure 2: Modes of transcriptional regulation during the YMC.

References

  1. Kouzarides, T. Cell 128, 693–705 (2007).

    Article  CAS  Google Scholar 

  2. Rando, O.J. & Winston, F. Genetics 190, 351–387 (2012).

    Article  CAS  Google Scholar 

  3. Kuang, Z. et al. Nat. Struct. Mol. Biol. 21, 854–863 (2014).

    Article  CAS  Google Scholar 

  4. Chance, B., Estabrook, R.W. & Ghosh, A. Proc. Natl. Acad. Sci. USA 51, 1244–1251 (1964).

    Article  CAS  Google Scholar 

  5. Lloyd, D. & Murray, D.B. Trends Biochem. Sci. 30, 373–377 (2005).

    Article  CAS  Google Scholar 

  6. Tu, B.P., Kudlicki, A., Rowicka, M. & McKnight, S.L. Science 310, 1152–1158 (2005).

    Article  CAS  Google Scholar 

  7. Bannister, A.J. & Kouzarides, T. Cell Res. 21, 381–395 (2011).

    Article  CAS  Google Scholar 

  8. Wozniak, G.G. & Strahl, B.D. Biochim. Biophys. Acta doi:10.1016/j.bbagrm.2014.03.002 (12 March 2014).

    Google Scholar 

  9. Santos-Rosa, H. et al. Nature 419, 407–411 (2002).

    Article  CAS  Google Scholar 

  10. Morillon, A., Karabetsou, N., Nair, A. & Mellor, J. Mol. Cell 18, 723–734 (2005).

    Article  CAS  Google Scholar 

  11. Carvin, C.D. & Kladde, M.P. J. Biol. Chem. 279, 33057–33062 (2004).

    Article  CAS  Google Scholar 

  12. Shi, X. et al. Nature 442, 96–99 (2006).

    Article  CAS  Google Scholar 

  13. Nourani, A., Utley, R.T., Allard, S. & Côté, J. EMBO J. 23, 2597–2607 (2004).

    Article  CAS  Google Scholar 

  14. Cai, L., Sutter, B.M., Li, B. & Tu, B.P. Mol Cell. 42, 426–437 (2011).

    Article  CAS  Google Scholar 

  15. Dion, M.F., Altschuler, S.J., Wu, L.F. & Rando, O.J. Proc. Natl. Acad. Sci. USA 102, 5501–5506 (2005).

    Article  CAS  Google Scholar 

  16. Laxman, S. & Tu, B.P. Curr. Opin. Genet. Dev. 20, 599–604 (2010).

    Article  CAS  Google Scholar 

  17. Laxman, S., Sutter, B.M. & Tu, B.P. PLoS ONE 5, e12595 (2010).

    Article  Google Scholar 

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Authors and Affiliations

  1. R. Magnus N. Friis and Michael C. Schultz are at the Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.,

    R Magnus N Friis & Michael C Schultz

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  1. R Magnus N Friis
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  2. Michael C Schultz
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Correspondence to Michael C Schultz.

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Friis, R., Schultz, M. The timing is right. Nat Struct Mol Biol 21, 846–847 (2014). https://doi.org/10.1038/nsmb.2898

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