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Delivering nonidentical twins

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Two sibling DNA polymerases synthesize most of the eukaryotic nuclear genome. A new study provides insights into the distinct protein interactions that deliver these replicases for asymmetric leading- and lagging-strand replication and reveals possible cross-talk between DNA replication and other cellular processes.

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Figure 1: Comparison of DNA polymerases δ and ε.
Figure 2: The eukaryotic replication fork.

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Acknowledgements

Research in the authors' laboratories is supported by Project Z01 ES065070 from the Division of Intramural Research of the US National Institutes of Health (National Institute of Environmental Health Sciences) to T.A.K. and by grant GM032431 from the US National Institutes of Health to P.M.B.

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Authors and Affiliations

  1. Thomas A. Kunkel is at the Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.,

    Thomas A Kunkel

  2. Peter M. Burgers is at the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.,

    Peter M Burgers

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  1. Thomas A Kunkel
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Correspondence to Thomas A Kunkel.

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Kunkel, T., Burgers, P. Delivering nonidentical twins. Nat Struct Mol Biol 21, 649–651 (2014). https://doi.org/10.1038/nsmb.2852

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