The past decade has witnessed an explosion in the identification of ubiquitin-ligase complexes as the missing receptors for important small-molecule hormones regulating plant growth and development. These breakthroughs were initiated by genetic approaches, with structural analysis providing mechanistic insights into how hormone perception and signaling are coupled to protein ubiquitination. Although there are still many unknowns, plants have imparted valuable lessons about the pharmacology of ubiquitin modification.
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Acknowledgements
N.Z. is supported as a Howard Hughes Medical Institute Investigator, with additional support provided by the US National Institutes of Health (R01-CA107134) and National Science Foundation (0929100).
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Shabek, N., Zheng, N. Plant ubiquitin ligases as signaling hubs. Nat Struct Mol Biol 21, 293–296 (2014). https://doi.org/10.1038/nsmb.2804
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DOI: https://doi.org/10.1038/nsmb.2804
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