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Grb-ing receptor activation by the tail

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Hyperactivation of receptor tyrosine kinase pathways is a common theme in cancer. The recent demonstration that an imbalance between the fibroblast growth factor receptor 2–binding proteins Grb2 and phospholipase C-γ1 can lead to invasive behavior in the absence of growth factors highlights an emerging concept in cellular-signaling homeostasis.

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Figure 1: Alternative mechanisms of PLCγ1 activation downstream of FGFR2.

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Authors and Affiliations

  1. Abbie E. Fearon and Richard P. Grose are at the Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.,

    Abbie E Fearon & Richard P Grose

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  1. Abbie E Fearon
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  2. Richard P Grose
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Correspondence to Richard P Grose.

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The authors declare no competing financial interests.

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Fearon, A., Grose, R. Grb-ing receptor activation by the tail. Nat Struct Mol Biol 21, 113–114 (2014). https://doi.org/10.1038/nsmb.2767

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